Literature DB >> 15089745

Segregation of two glutaminase isoforms in islets of Langerhans.

David Baglietto-Vargas1, Juan F López-Téllez, Inés Moreno-González, Antonia Gutiérrez, J Carlos Aledo.   

Abstract

Despite the importance of glutamatergic signalling in the co-ordination of hormone secretion, the identity of the enzyme for the production of glutamate in beta-cells is still unresolved. We have found that the endocrine pancreas co-expresses two isoforms of GA (glutaminase), denoted as kidney-type (KGA) and liver-type (LGA), with a complementary cellular pattern of expression. Whereas KGA was mainly present in alpha-cells, LGA was very abundant in beta-cells. This spatial segregation may have important functional implications, facilitating a differential regulation of glutamate production in insulin- and glucagon-secreting cells.

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Year:  2004        PMID： 15089745      PMCID： PMC1133855          DOI： 10.1042/BJ20040523

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  23 in total

1.  Isolation and characterization of the promoter region of the rat kidney-type glutaminase gene.

Authors:  L Taylor; X Liu; W Newsome; R A Shapiro; M Srinivasan; N P Curthoys
Journal:  Biochim Biophys Acta       Date:  2001-03-19

2.  Molecular cloning, sequencing and expression studies of the human breast cancer cell glutaminase.

Authors:  P M Gómez-Fabre; J C Aledo; A Del Castillo-Olivares; F J Alonso; I Núñez De Castro; J A Campos; J Márquez
Journal:  Biochem J       Date:  2000-01-15       Impact factor: 3.857

3.  Correlation between GABA release from rat islet beta-cells and their metabolic state.

Authors:  Frederic Winnock; Zhidong Ling; Rene De Proft; Sandra Dejonghe; Frans Schuit; Frans Gorus; Daniel Pipeleers
Journal:  Am J Physiol Endocrinol Metab       Date:  2002-04       Impact factor: 4.310

4.  Identification of two human glutaminase loci and tissue-specific expression of the two related genes.

Authors:  J C Aledo; P M Gómez-Fabre; L Olalla; J Márquez
Journal:  Mamm Genome       Date:  2000-12       Impact factor: 2.957

5.  Rat hepatic glutaminase: identification of the full coding sequence and characterization of a functional promoter.

Authors:  M I Chung-Bok; N Vincent; U Jhala; M Watford
Journal:  Biochem J       Date:  1997-05-15       Impact factor: 3.857

6.  Rat liver endothelial cell glutamine transporter and glutaminase expression contrast with parenchymal cells.

Authors:  R Lohmann; W W Souba; B P Bode
Journal:  Am J Physiol       Date:  1999-03

7.  Glutamate is not a messenger in insulin secretion.

Authors:  M J MacDonald; L A Fahien
Journal:  J Biol Chem       Date:  2000-11-03       Impact factor: 5.157

8.  Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis.

Authors:  P Maechler; C B Wollheim
Journal:  Nature       Date:  1999-12-09       Impact factor: 49.962

9.  Nuclear localization of L-type glutaminase in mammalian brain.

Authors:  Lucía Olalla; Antonia Gutiérrez; José A Campos; Zafar U Khan; Francisco J Alonso; Juan A Segura; Javier Márquez; J Carlos Aledo
Journal:  J Biol Chem       Date:  2002-08-05       Impact factor: 5.157

10.  The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related.

Authors:  Gyslaine Bertrand; Nobuyoshi Ishiyama; Myriam Nenquin; Magalie A Ravier; Jean-Claude Henquin
Journal:  J Biol Chem       Date:  2002-06-26       Impact factor: 5.157
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  10 in total

1.  Glutaminase dysregulation in HIV-1-infected human microglia mediates neurotoxicity: relevant to HIV-1-associated neurocognitive disorders.

Authors:  Yunlong Huang; Lixia Zhao; Beibei Jia; Li Wu; Yuju Li; Norman Curthoys; Jialin C Zheng
Journal:  J Neurosci       Date:  2011-10-19       Impact factor: 6.167

2.  Glutaminase C overexpression in the brain induces learning deficits, synaptic dysfunctions, and neuroinflammation in mice.

Authors:  Yi Wang; Yuju Li; Runze Zhao; Beiqing Wu; Blaise Lanoha; Zenghan Tong; Justin Peer; Jianhui Liu; Huangui Xiong; Yunlong Huang; Jialin Zheng
Journal:  Brain Behav Immun       Date:  2017-06-15       Impact factor: 7.217

3.  Proteome analysis and conditional deletion of the EAAT2 glutamate transporter provide evidence against a role of EAAT2 in pancreatic insulin secretion in mice.

Authors:  Yun Zhou; Leonie F Waanders; Silvia Holmseth; Caiying Guo; Urs V Berger; Yuchuan Li; Anne-Catherine Lehre; Knut P Lehre; Niels C Danbolt
Journal:  J Biol Chem       Date:  2013-11-26       Impact factor: 5.157

4.  In vitro glutaminase regulation and mechanisms of glutamate generation in HIV-1-infected macrophage.

Authors:  Nathan Erdmann; Changhai Tian; Yunlong Huang; Jianxing Zhao; Shelley Herek; Norman Curthoys; Jialin Zheng
Journal:  J Neurochem       Date:  2009-02-13       Impact factor: 5.372

5.  IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase.

Authors:  Ling Ye; Yunlong Huang; Lixia Zhao; Yuju Li; Lijun Sun; You Zhou; Guanxiang Qian; Jialin C Zheng
Journal:  J Neurochem       Date:  2013-05-03       Impact factor: 5.372

Review 6.  Role of diabetes mellitus on hepatic encephalopathy.

Authors:  Javier Ampuero; Isidora Ranchal; María del Mar Díaz-Herrero; José Antonio del Campo; Juan D Bautista; Manuel Romero-Gómez
Journal:  Metab Brain Dis       Date:  2012-11-24       Impact factor: 3.584

7.  Potentiation of Excitotoxicity in HIV-1 Associated Dementia and the Significance of Glutaminase.

Authors:  Nathan B Erdmann; Nick P Whitney; Jialin Zheng
Journal:  Clin Neurosci Res       Date:  2006-12

8.  Metformin inhibits glutaminase activity and protects against hepatic encephalopathy.

Authors:  Javier Ampuero; Isidora Ranchal; David Nuñez; María del Mar Díaz-Herrero; Marta Maraver; José Antonio del Campo; Ángela Rojas; Inés Camacho; Blanca Figueruela; Juan D Bautista; Manuel Romero-Gómez
Journal:  PLoS One       Date:  2012-11-15       Impact factor: 3.240

9.  Glutamate is an essential mediator in glutamine-amplified insulin secretion.

Authors:  Guirong Han; Harumi Takahashi; Naoya Murao; Ghupurjan Gheni; Norihide Yokoi; Yoshiyuki Hamamoto; Shun-Ichiro Asahara; Yutaka Seino; Yoshiaki Kido; Susumu Seino
Journal:  J Diabetes Investig       Date:  2021-02-17       Impact factor: 4.232

10.  Glutaminase 1 regulates the release of extracellular vesicles during neuroinflammation through key metabolic intermediate alpha-ketoglutarate.

Authors:  Beiqing Wu; Jianhui Liu; Runze Zhao; Yuju Li; Justin Peer; Alexander L Braun; Lixia Zhao; Yi Wang; Zenghan Tong; Yunlong Huang; Jialin C Zheng
Journal:  J Neuroinflammation       Date:  2018-03-14       Impact factor: 8.322
  10 in total

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