[Implantation of a bio-artificial insulin distributor in dogs, using islets of Langerhans from different animal species].

In the diabetic dog, the implantation of a bioartificial insulin distributor (Biard) producted a temporary normoglycemia, using islets of Langerhans isolated from dog pancreas and cultured on the outer surface of the hollow fibers (XM 50). In a diabetic dog receiving the Biard using porcine isolated islets, the hyperglycemia was partially corrected during two days. In a diabetic dog due to implantation of human isolated islets the slight rise of insulin and human C-peptide is not accompanied by significant decrease in hyperglycemia. However, in another diabetic dog the Biard implantation of human islets provoked a significant increase of insulin and human C-peptide in the blood, with partial normalisation of hyperglycemia during two days.