Literature DB >> 15087123

Sequence analysis of 0.5 Mb of the rabbit germline immunoglobulin heavy chain locus.

Francesca Ros1, Juergen Puels, Nicole Reichenberger, Wim van Schooten, Roland Buelow, Josef Platzer.   

Abstract

A bacterial artificial chromosome (BAC) library was created using partially digested rabbit chromosomal DNA. Four BAC clones spanning about 0.5 Mb of the rabbit immunoglobulin (Ig) heavy chain locus were isolated and sequenced. Three of the BAC clones were partially overlapping. Thirty-four V elements, 11 D elements, DQ52, six J elements and the coding regions of Cmicro, Cgamma, C and four Calpha genes were identified and characterized. Additionally, the sequence of a fosmid clone spanning Calpha13 and 30 kb 3'enhancer region was determined. The organization of the locus and the potential function of newly identified functional and structural elements are discussed.

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Year:  2004        PMID： 15087123     DOI： 10.1016/j.gene.2003.12.037

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  22 in total

1.  Sequencing of Sylvilagus VDJ genes reveals a new VHa allelic lineage and shows that ancient VH lineages were retained differently in leporids.

Authors:  Ana Pinheiro; José Melo-Ferreira; Joana Abrantes; Nicola Martinelli; Antonio Lavazza; Paulo C Alves; Christian Gortázar; Pedro J Esteves
Journal:  Immunogenetics       Date:  2014-09-30       Impact factor: 2.846

Review 2.  An overview of the lagomorph immune system and its genetic diversity.

Authors:  Ana Pinheiro; Fabiana Neves; Ana Lemos de Matos; Joana Abrantes; Wessel van der Loo; Rose Mage; Pedro José Esteves
Journal:  Immunogenetics       Date:  2015-09-23       Impact factor: 2.846

3.  Activation-induced deaminase cloning, localization, and protein extraction from young VH-mutant rabbit appendix.

Authors:  Guibin Yang; Harold Obiakor; Rajesh K Sinha; Barbara A Newman; Brian L Hood; Thomas P Conrads; Timothy D Veenstra; Rose G Mage
Journal:  Proc Natl Acad Sci U S A       Date:  2005-11-09       Impact factor: 11.205

4.  The evolution of the immunoglobulin heavy chain variable region (IgVH) in Leporids: an unusual case of transspecies polymorphism.

Authors:  P J Esteves; D Lanning; N Ferrand; K L Knight; S K Zhai; W van der Loo
Journal:  Immunogenetics       Date:  2005-10-25       Impact factor: 2.846

5.  The functional repertoire of rabbit antibodies and antibody discovery via next-generation sequencing.

Authors:  Sreekumar Kodangattil; Christine Huard; Cindy Ross; Jian Li; Huilan Gao; Alessandro Mascioni; Santosh Hodawadekar; Snehal Naik; Jessica Min-debartolo; Alberto Visintin; Juan C Almagro
Journal:  MAbs       Date:  2014-01-30       Impact factor: 5.857

Review 6.  Molecular bases of genetic diversity and evolution of the immunoglobulin heavy chain variable region (IGHV) gene locus in leporids.

Authors:  Ana Pinheiro; Dennis Lanning; Paulo C Alves; Rose G Mage; Katherine L Knight; Wessel van der Loo; Pedro J Esteves
Journal:  Immunogenetics       Date:  2011-05-20       Impact factor: 2.846

7.  Construction of a cytogenetically anchored microsatellite map in rabbit.

Authors:  Céline Chantry-Darmon; Céline Urien; Hélène Hayes; Maud Bertaud; Sead Chadi-Taourit; Patrick Chardon; Daniel Vaiman; Claire Rogel-Gaillard
Journal:  Mamm Genome       Date:  2005-06       Impact factor: 2.957

8.  Rabbit anti-HIV-1 monoclonal antibodies raised by immunization can mimic the antigen-binding modes of antibodies derived from HIV-1-infected humans.

Authors:  Ruimin Pan; Jared M Sampson; Yuxin Chen; Michael Vaine; Shixia Wang; Shan Lu; Xiang-Peng Kong
Journal:  J Virol       Date:  2013-07-17       Impact factor: 5.103

9.  Accuracy and coverage assessment of Oryctolagus cuniculus (rabbit) genes encoding immunoglobulins in the whole genome sequence assembly (OryCun2.0) and localization of the IGH locus to chromosome 20.

Authors:  E Michael Gertz; Alejandro A Schäffer; Richa Agarwala; Amélie Bonnet-Garnier; Claire Rogel-Gaillard; Hélène Hayes; Rose G Mage
Journal:  Immunogenetics       Date:  2013-08-08       Impact factor: 2.846

10.  Sequencing of modern Lepus VDJ genes shows that the usage of VHn genes has been retained in both Oryctolagus and Lepus that diverged 12 million years ago.

Authors:  Ana Pinheiro; Isabel G Fernández de Mera; Paulo C Alves; Christian Gortázar; José de la Fuente; Pedro J Esteves
Journal:  Immunogenetics       Date:  2013-08-24       Impact factor: 2.846
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