Literature DB >> 15084780

The confounding of race and geography: how much of the excess stroke mortality among African Americans is explained by geography?

Dongyan Yang1, George Howard, Christopher S Coffey, Jeffrey Roseman.   

Abstract

INTRODUCTION: The excess stroke mortality among African Americans and Southerners is well known. Because a higher proportion of the population living in the 'Stroke Belt' is African American, then a portion of the estimated excess risk of stroke death traditionally associated with African-American race may be attributable to geography (i.e., race and geography are 'confounded'). In this paper we estimate the proportion of the excess stroke mortality among African Americans that is attributable to geography.
METHODS: The numbers of stroke deaths at the county level are available from the vital statistics system of the US. A total of 1,143 counties with a population of at least 500 whites and 500 African Americans were selected for these analyses. The black-to-white stroke mortality ratio was estimated with and without adjustment for county of residence for those aged 45-64 and for those aged 65 and over. The difference in the stroke mortality ratio before versus after adjustment for county provides an estimate of the proportion of the excess stroke mortality inappropriately attributed to race (that is in fact attributable to geographic region).
RESULTS: For ages 45-64, the black-to-white stroke mortality ratio was reduced from 3.41 to 3.04 for men, and from 2.82 to 2.60 for women, suggesting that between 10 and 15% of the excess mortality traditionally attributed to race is rather due to geography. Over the age of 65, the black-to-white stroke mortality ratio was reduced from 1.31 to 1.27 for men, and from 1.097 to 1.095 for women, suggesting that between 2 and 13% of the excess mortality attributed to black race is actually attributable to geography. The reductions of all the four age strata gender groups were highly significant. DISCUSSION: These results suggest that a significant, although relatively small, proportion of the excess mortality traditionally attributed to race is rather a factor of geography. Copyright 2004 S. Karger AG, Basel

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Year:  2004        PMID: 15084780     DOI: 10.1159/000075954

Source DB:  PubMed          Journal:  Neuroepidemiology        ISSN: 0251-5350            Impact factor:   3.282


  17 in total

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4.  Addressing geographic confounding through spatial propensity scores: a study of racial disparities in diabetes.

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5.  Incident cognitive impairment is elevated in the stroke belt: the REGARDS study.

Authors:  Virginia G Wadley; Frederick W Unverzagt; Lisa C McGuire; Claudia S Moy; Rodney Go; Brett Kissela; Leslie A McClure; Michael Crowe; Virginia J Howard; George Howard
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6.  Dietary patterns are associated with incident stroke and contribute to excess risk of stroke in black Americans.

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8.  Regional differences in African Americans' high risk for stroke: the remarkable burden of stroke for Southern African Americans.

Authors:  George Howard; Darwin R Labarthe; Jianfang Hu; Sarah Yoon; Virginia J Howard
Journal:  Ann Epidemiol       Date:  2007-09       Impact factor: 3.797

9.  Effect of duration and age at exposure to the Stroke Belt on incident stroke in adulthood.

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Journal:  Neurology       Date:  2009-12-01       Impact factor: 9.910

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