| Literature DB >> 1508404 |
G S Mitchell1, H E Sloan, C Jiang, V Miletic, F Hayashi, J Lipski.
Abstract
Experiments on anesthetized, spinalized rats were conducted to determine the effects of systemic 5-hydroxytryptophan (5-HTP) administration on: (1) spontaneous phrenic nerve activity and (2) evoked phrenic responses to short latency, non-serotonergic synaptic inputs elicited by electrical stimulation of lateral funiculus. 5-HTP augmented spontaneous phrenic activity and allowed expression of a second, longer latency evoked response. Both effects were antagonized by methysergide. Our results suggest that spinal serotonin increases the efficacy of synaptic inputs to phrenic motoneurons.Entities:
Mesh：
Substances：
Year: 1992 PMID： 1508404 DOI： 10.1016/0304-3940(92)90338-8
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046