Literature DB >> 1508392

Evidence for genetic determination in human twins of olfactory thresholds for a standard odorant.

R Gross-Isseroff1, D Ophir, A Bartana, H Voet, D Lancet.   

Abstract

Olfactory thresholds for four odorants were determined in groups of monozygotic and dizygotic human twins. Odorants were presented in an ascending dilution series in odorless solvent, using a three-way forced choice method. For two of the tested odorants, 5 alpha-androst-16-en-3-one and isoamyl acetate, the thresholds showed a strong genetic component. This was demonstrated by respective values of 0.78 and 0.73 for the intraclass correlation difference, and of z = 3.69 and z = 2.71 in a within-pair difference analysis. The results for isoamyl acetate are novel, and suggest that genetic polymorphism in the affinity of odorant receptor proteins contributes to the (nearly normal) threshold distribution for this odorant.

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Year:  1992        PMID： 1508392     DOI： 10.1016/0304-3940(92)90347-a

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  11 in total

1.  Genetic and environmental influences on odor identification ability in the very old.

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4.  Probability model for molecular recognition in biological receptor repertoires: significance to the olfactory system.

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5.  Familial aggregation of olfactory impairment and odor identification in older adults.

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6.  An olfactory demography of a diverse metropolitan population.

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Review 7.  Co-regulation of a large and rapidly evolving repertoire of odorant receptor genes.

Authors:  Marijo B Kambere; Robert P Lane
Journal:  BMC Neurosci       Date:  2007-09-18       Impact factor: 3.288

8.  Genetic elucidation of human hyperosmia to isovaleric acid.

Authors:  Idan Menashe; Tatjana Abaffy; Yehudit Hasin; Sivan Goshen; Vered Yahalom; Charles W Luetje; Doron Lancet
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9.  High-resolution copy-number variation map reflects human olfactory receptor diversity and evolution.

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10.  Bias of selection on human copy-number variants.

Authors:  Duc-Quang Nguyen; Caleb Webber; Chris P Ponting
Journal:  PLoS Genet       Date:  2006-02-17       Impact factor: 5.917
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