| Literature DB >> 15081525 |
Anna Erdei1, Márton Andrásfalvy, Hajna Péterfy, Gábor Tóth, Israel Pecht.
Abstract
It is known for more than 25 years that the complement-derived anaphylatoxic peptides, C3a, C4a and C5a are potent activators of basophils and certain types of mast cells. Although tissue distribution of receptors for C3a and C5a well exceeds myeloid cells, apparently they are not expressed on mucosal type mast cells, consequently these cells are not activated by C3a and C5a. Our results do however demonstrate that C3a and peptides related to this complement activation product are able to inhibit FcRI-clustering induced activation of mucosal type mast cells-such as RBL-2H3 cells and bone-marrow derived mast cells. Based on the current results we propose the presence of separate "activator" and "inhibitor" sequence motifs in C3a which are in balance under physiologic conditions.Entities:
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Year: 2004 PMID： 15081525 DOI： 10.1016/j.imlet.2003.11.019
Source DB: PubMed Journal: Immunol Lett ISSN： 0165-2478 Impact factor: 3.685