| Literature DB >> 15081263 |
Clara Ballerini1, Franca R Guerini, Giovanni Rombolà, Eleonora Rosati, Luca Massacesi, Pasquale Ferrante, Domenico Caputo, Lorenzo Figà Talamanca, Paola Naldi, Maria Liguori, Mehdi Alizadeh, Patricia Momigliano-Richiardi, Sandra D'Alfonso.
Abstract
The association with HLA-DRB1 alleles was tested in 609 Continental Italian MS patients and 836 controls. The phenotype frequency of DRB1*15 in the patients was significantly higher (0.316 vs. 0.112; p(c)<10(-6); Odds Ratio (OR)=3.64) with no dose effect. DRB1*10 was also significantly increased (OR=2.19; p(c)=0.047) and DRB1*07 decreased (OR=0.60; p(c)=1.3 x 10(-3)) independently of DR15 and of each other. We did not detect an influence of the DR phenotype on disease course, age at onset/diagnosis, gender or familiarity. No association with Class I was detected in a random subset of patients and controls. A comparison of the HLA association data in Northern and Southern European populations shows a parallel between disease prevalence and DR15 frequency.Entities:
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Year: 2004 PMID： 15081263 DOI： 10.1016/j.jneuroim.2004.01.015
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478