| Literature DB >> 15081029 |
Baoqing Gong1, Feng Hong, Cory Kohm, Scott Jenkins, John Tulinsky, Rama Bhatt, Peter De Vries, Jack W Singer, Peter Klein.
Abstract
2,4-Diamino-N(4),6-diarylpyrimidines were identified as potent, isoform specific inhibitors of lysophosphatidic acid acyltransferase-beta (LPAAT-beta). Active inhibitors also blocked proliferation of tumor cell lines in vitro. The effect of 2j in an in vivo tumor model was investigated.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15081029 DOI： 10.1016/j.bmcl.2004.01.104
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823