| Literature DB >> 15081024 |
Vinod R Hegde1, Haiyan Pu, Mahesh Patel, Todd Black, Aileen Soriano, Wenjun Zhao, Vincent P Gullo, Tze-Ming Chan.
Abstract
The 70% aqueous methanolic extract of the Peruvian plant Polygonum cuspidatum sp. was found to contain two novel phenolic saccharides 1 and 2, which were identified as inhibitors of the bacterial DNA primase enzyme. Structures of these two compounds were established based on high resolution NMR studies. Compound 1 and 2 inhibited the primase enzyme with an IC(50) of 4 and 5 microM, respectively.Entities:
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Year: 2004 PMID： 15081024 DOI： 10.1016/j.bmcl.2004.02.006
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823