| Literature DB >> 15081016 |
Massimo Curini1, Francesco Epifano, Federica Maltese, Maria C Marcotullio, Aurelia Tubaro, Gianmario Altinier, Sylvia Prieto Gonzales, Juan C Rodriguez.
Abstract
Nine new 7-geranyloxycoumarin derivatives differently substituted at position 8 were semi-synthesised. Their topical anti-inflammatory activity was evaluated using the Croton oil ear test in mice as a model of acute inflammation. Auraptene (7-geranyloxycoumarin), its 8-methoxy (collinin, 1) and 8-acetoxy derivatives (5) (1 micromol/cm(2)) provoked 50% oedema reduction, similarly to 0.25 micromol/cm(2) of the reference drug indomethacin, a nonsteroidal anti-inflammatory drug.Entities:
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Year: 2004 PMID： 15081016 DOI： 10.1016/j.bmcl.2004.02.009
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823