| Literature DB >> 15081013 |
Ligong Liu1, Cai Ping Li, Siska Cochran, Vito Ferro.
Abstract
A focused library of novel, sulfated glycoconjugates was synthesized by utilizing carbohydrate-derived blocks in the four-component Ugi condensation. Library members comprise a sulfated monosaccharide linked by various spacers to either an aromatic or monosulfated moiety, or a second sulfated monosaccharide. The affinities of these heparan sulfate (HS) mimetics for the HS-binding fibroblast growth factors FGF-1 and FGF-2 were measured via a surface plasmon resonance solution affinity assay.Entities:
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Year: 2004 PMID： 15081013 DOI： 10.1016/j.bmcl.2004.02.017
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823