| Literature DB >> 15080996 |
Philippe G Nantermet1, James C Barrow, Stacey R Lindsley, MaryBeth Young, Shi-Shan Mao, Steven Carroll, Carolyn Bailey, Michele Bosserman, Dennis Colussi, Daniel R McMasters, Joseph P Vacca, Harold G Selnick.
Abstract
Structural modifications of the aminopyridine P(1)(') group of imidazole acetic acid based TAFIa inhibitors led to the discovery of the aminocyclopentyl analog 28, a 1 nM TAFIa inhibitor with CLT(50) functional activity of 14 nM but without selectivity against CPB. While not as active, aminobutyl derivative 27 provided an improved 6.7-fold selectivity for TAFIa versus CPB.Entities:
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Year: 2004 PMID： 15080996 DOI： 10.1016/j.bmcl.2004.02.033
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823