Literature DB >> 15080982

Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists.

Irini Akritopoulou-Zanze1, Jyoti R Patel, Kresna Hartandi, Jehrod Brenneman, Martin Winn, John K Pratt, Marlene Grynfarb, Annika Goos-Nisson, Thomas W Von Geldern, Philip R Kym.   

Abstract

We report the discovery of a novel class of glucocorticoid receptor (GR) antagonists based on the chromene molecular scaffold. The compounds exhibit good functional potency and an improved receptor selectivity profile for GR over other steroid receptors when compared to the classical steroidal GR-antagonist, RU-486.

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Year:  2004        PMID： 15080982     DOI： 10.1016/j.bmcl.2004.02.048

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  The design, synthesis, and evaluation of coumarin ring derivatives of the novobiocin scaffold that exhibit antiproliferative activity.

Authors:  Alison C Donnelly; Jared R Mays; Joseph A Burlison; John T Nelson; George Vielhauer; Jeffrey Holzbeierlein; Brian S J Blagg
Journal:  J Org Chem       Date:  2008-10-22       Impact factor: 4.354

2.  Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis.

Authors:  Chae Jin Lim; Yong-Moon Lee; Seung Goo Kang; Hyung W Lim; Kyong-Oh Shin; Se Kyoo Jeong; Yang Hoon Huh; Suin Choi; Myungho Kor; Ho Seong Seo; Byeong Deog Park; Keedon Park; Jeong Keun Ahn; Yoshikazu Uchida; Kyungho Park
Journal:  Biomol Ther (Seoul)       Date:  2017-09-01       Impact factor: 4.634
  2 in total

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