| Literature DB >> 15080977 |
Ali Cagir1, Shannon H Jones, Brian M Eisenhauer, Rong Gao, Sidney M Hecht.
Abstract
Luotonin A is a cytotoxic pyrroloquinazolinoquinoline alkaloid that has been shown to stabilize the human topoisomerase I-DNA covalent binary complex in the same fashion as the antitumor alkaloid camptothecin. A study of the structural elements in luotonin A required for binary complex stabilization has revealed key differences relative to those required for camptothecin.Entities:
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Year: 2004 PMID： 15080977 DOI： 10.1016/j.bmcl.2004.02.069
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823