Literature DB >> 15080926

QSAR study on phenolic activity: need of positive hydrophobic term (log P) in QSAR.

Mamta Thakur1, Alok Agarwal, Abhilash Thakur, Padmakar V Khadikar.   

Abstract

The phenolic activity (log 1/C) of a large series of phenols against L1210 leukaemia cells was modelled using physicochemical parameters other than conventional electronic and steric parameters. Attempts have also been made to examine need or otherwise of the hydrophobic parameter, log P, in such studies. The results have shown that contribution of log P in modelling log 1/C is favourable.

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Year:  2004        PMID: 15080926     DOI: 10.1016/j.bmc.2004.02.010

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN: 0968-0896            Impact factor:   3.641


  2 in total

1.  QSAR models of cytochrome P450 enzyme 1A2 inhibitors using CoMFA, CoMSIA and HQSAR.

Authors:  J Sridhar; M Foroozesh; C L Klein Stevens
Journal:  SAR QSAR Environ Res       Date:  2011-10-17       Impact factor: 3.000

2.  3D-QSAR studies on caspase-mediated apoptosis activity of phenolic analogues.

Authors:  Yuanqiang Wang; Heng Zhang; Yong Lin; Qi Zhao; Hui Liu; Zhan Zhang; Qingyou Xia; Bo Zhu; Zhihua Lin
Journal:  J Mol Model       Date:  2010-03-21       Impact factor: 1.810

  2 in total

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