Lucia F Bricks1. 1. Dep. de Pediatria da FMUSP, and Instituto da Criança do Hospital das Clínicas da Fac. de Medicina da Univ. da São Paulo, Sao Paulo, SP. luciafb@icr.hcnet.usp.br
Abstract
OBJECTIVE: To compare the intradermal and percutaneous routes of BCG administration. SOURCES OF DATA: A review of the literature published between 1987 and 2002 was carried out in the MEDLINE and Lilacs databases. The following key words were used: BCG vaccine/administration, adverse effects, efficacy, tuberculosis/prevention and control. Some articles published before 1987 were included because of their relevance to the topic. SUMMARY OF THE FINDINGS: There are no clinical studies comparing the efficacy of intradermal and percutaneous BCG. Percutaneous BCG causes a weaker reaction, however it is also less efficient in stimulating gamma-interferon production by Th1-lymphocytes, which is considered as the best marker of the anti-tuberculin immune response. CONCLUSIONS: In vivo and in vitro studies suggest a better immune response with intradermal BCG. The intradermal method should be recommended for BCG administration.
OBJECTIVE: To compare the intradermal and percutaneous routes of BCG administration. SOURCES OF DATA: A review of the literature published between 1987 and 2002 was carried out in the MEDLINE and Lilacs databases. The following key words were used: BCG vaccine/administration, adverse effects, efficacy, tuberculosis/prevention and control. Some articles published before 1987 were included because of their relevance to the topic. SUMMARY OF THE FINDINGS: There are no clinical studies comparing the efficacy of intradermal and percutaneous BCG. Percutaneous BCG causes a weaker reaction, however it is also less efficient in stimulating gamma-interferon production by Th1-lymphocytes, which is considered as the best marker of the anti-tuberculin immune response. CONCLUSIONS: In vivo and in vitro studies suggest a better immune response with intradermal BCG. The intradermal method should be recommended for BCG administration.
Authors: Beatriz Beltrán-Beck; Beatriz Romero; Iker A Sevilla; Jose A Barasona; Joseba M Garrido; David González-Barrio; Iratxe Díez-Delgado; Esmeralda Minguijón; Carmen Casal; Joaquín Vicente; Christian Gortázar; Alicia Aranaz Journal: Clin Vaccine Immunol Date: 2013-10-30
Authors: Maria Fernanda Reis Gavazzoni Dias; Fred Bernardes Filho; Maria Victória Quaresma; Leninha Valério do Nascimento; José Augusto da Costa Nery; David Rubem Azulay Journal: An Bras Dermatol Date: 2014 Nov-Dec Impact factor: 1.896
Authors: Anthony Hawkridge; Mark Hatherill; Francesca Little; Margaret Ann Goetz; Lew Barker; Hassan Mahomed; Jerald Sadoff; Willem Hanekom; Larry Geiter; Greg Hussey Journal: BMJ Date: 2008-11-13