Literature DB >> 15079031

Cognitive functioning in humans with mutations of the PAX6 gene.

P J Thompson1, T N Mitchell, S L Free, K A Williamson, I M Hanson, V van Heyningen, A T Moore, S M Sisodiya.   

Abstract

Fourteen patients with PAX6 gene mutations and previously identified MRI abnormalities were administered tests of cognitive functioning. No deficits were found. A subgroup with agenesis of the anterior commissure performed significantly more poorly on measures of working memory than those without this abnormality, suggesting the anterior commissure may play a role in cognitive processing in addition to an earlier identified role in sensory development and processing.

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Year:  2004        PMID： 15079031     DOI： 10.1212/01.wnl.0000118298.81140.62

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  12 in total

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