| Literature DB >> 15079025 |
A J C Slooter1, M Cruts, A Hofman, P J Koudstaal, D van der Kuip, M A J de Ridder, J C M Witteman, M M B Breteler, C Van Broeckhoven, C M van Duijn.
Abstract
It is unclear how the APOE genotype contributes to the incidence of vascular diseases and dementia. In a population-based sample (n = 6,852) with complete follow-up, APOE was weakly associated with myocardial infarction and not related with stroke. In the absence of epsilon4, the incidence of dementia would be 25.8% lower; in the absence of epsilon2/epsilon3, 2.8% higher. Risk estimates of dementia, specified for age, sex, and APOE, are provided for counseling. APOE is not strongly related to vascular diseases, but contributes substantially to dementia incidence.Entities:
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Year: 2004 PMID： 15079025 DOI： 10.1212/01.wnl.0000118302.66674.e1
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910