Literature DB >> 15078973

Delivery of short hairpin RNA sequences by using a replication-competent avian retroviral vector.

Jennifer L Bromberg-White1, Craig P Webb, Veronique S Patacsil, Cindy K Miranti, Bart O Williams, Sheri L Holmen.   

Abstract

While recent studies have demonstrated that retroviral vectors can be used to stably express short hairpin RNA (shRNA) to inhibit gene expression, these studies have utilized replication-defective retroviruses. We describe the creation of a replication-competent, Gateway-compatible retroviral vector capable of expressing shRNA that inhibits the expression of specific genes.

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Year:  2004        PMID： 15078973      PMCID： PMC387706          DOI： 10.1128/jvi.78.9.4914-4916.2004

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


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