Literature DB >> 15078

Synthesis and pharmacological properties of a series of antidopaminergic piperidyl benzamides.

J Prieto, J Moragues, R G Spickett, A Vega, M Colombo, W Salazar, D J Roberts.   

Abstract

The synthesis and pharmacological screening for anti-apomorphine, stomach emptying and local anaesthetic activities of some new piperidylbenzamides is described. One of these, N-(1'-benzyl-4'-piperidyl)-2-methoxy-4-amino-5-chlorobenzamide (clebopride) is more potent than metoclopramide in tests related to blockade of cerebral dopamine receptors.

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Year:  1977        PMID: 15078     DOI: 10.1111/j.2042-7158.1977.tb11272.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN: 0022-3573            Impact factor:   3.765


  3 in total

1.  Differential effects of benzamides and thioxanthenes on dopamine-elicited accumulation of cyclic AMP in isolated rabbit retina.

Authors:  P Magistretti; M Schorderet
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-06       Impact factor: 3.000

2.  Effects of clozapine in a selective muscarinic bioassay and on single cells of the rat hippocampus.

Authors:  P L Herrling; B Misbach-Lesenne
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-07       Impact factor: 3.000

3.  Crystal structure of human PLD1 provides insight into activation by PI(4,5)P2 and RhoA.

Authors:  Forrest Z Bowling; Christian M Salazar; Justin A Bell; Tahrima S Huq; Michael A Frohman; Michael V Airola
Journal:  Nat Chem Biol       Date:  2020-03-16       Impact factor: 15.040

  3 in total

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