| Literature DB >> 150778 |
E Misaka, K Matsuda, K Kobayashi, Y Endo, T Kojima, Y Iizuka.
Abstract
An anti-inflammatory factor (AIF) was highly purified from normal bovine serum. The purified AIF was a polysaccharide which was formed from a low molecular substance Pro-AIF by macromolecularization. AIF showed potent inhibitory activities against carrageenin induced edema in rats and PMN-leucocyte chemotaxis. It showed no inhibition in cutaneous reaction with serotonin, bradykinin or a mediator releaser compound 48/80. No inhibition was also observed in thermally induced pain, reversed passive Arthus reaction and adjuvant polyarthritis in rats. With these results, the role of AIF in inflammation was discussed.Entities:
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Year: 1978 PMID： 150778 DOI： 10.1007/bf01968674
Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299