OBJECTIVES: To investigate the prevalence of Helicobacter pylori infection in a randomly selected population of children from a low income community in Brazil and the risk factors for infection. DESIGN: A cross-sectional, randomised study of prevalence and risk factors. SUBJECTS:Children living in an urban community in north-east Brazil. METHODS:H. pylori infection was determined using the C-urea breath test. Risk factors were assessed using a structured interview schedule. RESULTS: The overall prevalence of H. pylori was 56% (197/353). The infection was most common for those aged 12-14 years. In this group 75.4% (49/65) (95% CI, 63.1-85) of all children were positive for H. pylori, while in children less than 2 years of age 35.1% (13/37) (95% CI, 20.2-52.5) were positive. The prevalence of H. pylori increased significantly with age (P < 0.0001). In the bivariate analysis, a significant difference was found in the prevalence of H. pylori infection and age, number of persons per room, the number of children per household, cup sharing, and type of drinking water (P < 0.05). However, after logistic regression modelling only age (odds ratio (OR) = 1.3; 95% confidence interval (CI), 1.07-1.65), and number of persons per room (OR = 2.58; 95% CI, 1.4-4.6) were risk factors for H. pylori infection. CONCLUSIONS: H. pylori is highly prevalent among children in a north-eastern Brazilian community characterised by poor living conditions, and this infection is largely acquired during early childhood. The infection increased with age, and domestic overcrowding. Further longitudinal studies must examine in depth the possible modes of transmission of the organism in young children.
RCT Entities:
OBJECTIVES: To investigate the prevalence of Helicobacter pylori infection in a randomly selected population of children from a low income community in Brazil and the risk factors for infection. DESIGN: A cross-sectional, randomised study of prevalence and risk factors. SUBJECTS:Children living in an urban community in north-east Brazil. METHODS:H. pyloriinfection was determined using the C-urea breath test. Risk factors were assessed using a structured interview schedule. RESULTS: The overall prevalence of H. pylori was 56% (197/353). The infection was most common for those aged 12-14 years. In this group 75.4% (49/65) (95% CI, 63.1-85) of all children were positive for H. pylori, while in children less than 2 years of age 35.1% (13/37) (95% CI, 20.2-52.5) were positive. The prevalence of H. pylori increased significantly with age (P < 0.0001). In the bivariate analysis, a significant difference was found in the prevalence of H. pyloriinfection and age, number of persons per room, the number of children per household, cup sharing, and type of drinking water (P < 0.05). However, after logistic regression modelling only age (odds ratio (OR) = 1.3; 95% confidence interval (CI), 1.07-1.65), and number of persons per room (OR = 2.58; 95% CI, 1.4-4.6) were risk factors for H. pyloriinfection. CONCLUSIONS:H. pylori is highly prevalent among children in a north-eastern Brazilian community characterised by poor living conditions, and this infection is largely acquired during early childhood. The infection increased with age, and domestic overcrowding. Further longitudinal studies must examine in depth the possible modes of transmission of the organism in young children.
Authors: Maria H R B Goncalves; Cícero I S M Silva; Manuel B Braga-Neto; Andrea B C Fialho; Andre M N Fialho; Dulciene M M Queiroz; Lucia L B C Braga Journal: J Clin Microbiol Date: 2012-12-19 Impact factor: 5.948
Authors: Caroline M den Hoed; Anne J Vila; Ingrid L Holster; Guillermo I Perez-Perez; Martin J Blaser; Johan C de Jongste; Ernest J Kuipers Journal: Helicobacter Date: 2011-10 Impact factor: 5.753
Authors: Lucy S Ito; Sueli M Oba-Shinjo; Samuel K Shinjo; Miyuki Uno; Suely K N Marie; Nobuyuki Hamajima Journal: Gastric Cancer Date: 2006 Impact factor: 7.370
Authors: Tiago Gomes da Silva Benigno; Howard Lopes Ribeiro Junior; Orleâncio Gomes Ripardo de Azevedo; Ronald Feitosa Pinheiro; Roberta Taiane Germano de Oliveira; Felipe Silva Maciel; Edson Luiz de Oliveira; Dulciene Maria Magalhães Queiroz; Lucia Libanez Bessa Campelo Braga Journal: Rev Inst Med Trop Sao Paulo Date: 2022-07-13 Impact factor: 2.169
Authors: Vitor Camilo Cavalcante Dattoli; Rafael Valente Veiga; Sergio Souza da Cunha; Lain Carlos Pontes-de-Carvalho; Maurício Lima Barreto; Neuza Maria Alcântara-Neves Journal: Helicobacter Date: 2010-08 Impact factor: 5.753
Authors: Ina S Santos; Jose Boccio; Ari S Santos; Neiva C J Valle; Camila S Halal; Marta Colvara Bachilli; Ricardo D Lopes Journal: BMC Public Health Date: 2005-11-10 Impact factor: 3.295