Stephen M Roth1, Sean Walsh. 1. Department of Kinesiology, College of Health and Human Performance, University of Maryland, College Park, Maryland 20742, USA. sroth1@umd.edu
Abstract
PURPOSE OF REVIEW: This review discusses recent developments in myostatin research, focusing on the basic actions of myostatin on skeletal muscle, the identification of key regulatory elements of the myostatin pathway, and the promise of myostatin as a therapeutic target in muscle-related disorders. RECENT FINDINGS: In addition to a well-characterized role in muscle development, recent research advances have solidified the importance of myostatin in adult muscle, although questions remain. A number of possible regulatory proteins for myostatin have been identified, showing a complex picture of myostatin regulation that requires clarification. The identification of an antimyostatin monoclonal antibody (JA16) shows the promise of myostatin as a target for muscle-wasting disorders; the antibody has already been shown to increase muscle mass in healthy older mice and muscle function in postnatal mdx mice. SUMMARY: Since its discovery in 1997, myostatin has quickly been established as a key regulator of skeletal muscle mass. Recent developments strengthen the idea that myostatin will be an important therapeutic target for muscle-wasting-related disorders, and as more details of myostatin regulation and its mechanisms of action are clarified, myostatin will continue to dominate the skeletal muscle development and muscle-wasting literature.
PURPOSE OF REVIEW: This review discusses recent developments in myostatin research, focusing on the basic actions of myostatin on skeletal muscle, the identification of key regulatory elements of the myostatin pathway, and the promise of myostatin as a therapeutic target in muscle-related disorders. RECENT FINDINGS: In addition to a well-characterized role in muscle development, recent research advances have solidified the importance of myostatin in adult muscle, although questions remain. A number of possible regulatory proteins for myostatin have been identified, showing a complex picture of myostatin regulation that requires clarification. The identification of an antimyostatin monoclonal antibody (JA16) shows the promise of myostatin as a target for muscle-wasting disorders; the antibody has already been shown to increase muscle mass in healthy older mice and muscle function in postnatal mdx mice. SUMMARY: Since its discovery in 1997, myostatin has quickly been established as a key regulator of skeletal muscle mass. Recent developments strengthen the idea that myostatin will be an important therapeutic target for muscle-wasting-related disorders, and as more details of myostatin regulation and its mechanisms of action are clarified, myostatin will continue to dominate the skeletal muscle development and muscle-wasting literature.
Authors: C Cooper; W Dere; W Evans; J A Kanis; R Rizzoli; A A Sayer; C C Sieber; J-M Kaufman; G Abellan van Kan; S Boonen; J Adachi; B Mitlak; Y Tsouderos; Y Rolland; J-Y L Reginster Journal: Osteoporos Int Date: 2012-07 Impact factor: 4.507
Authors: François Maltais; Marc Decramer; Richard Casaburi; Esther Barreiro; Yan Burelle; Richard Debigaré; P N Richard Dekhuijzen; Frits Franssen; Ghislaine Gayan-Ramirez; Joaquim Gea; Harry R Gosker; Rik Gosselink; Maurice Hayot; Sabah N A Hussain; Wim Janssens; Micheal I Polkey; Josep Roca; Didier Saey; Annemie M W J Schols; Martijn A Spruit; Michael Steiner; Tanja Taivassalo; Thierry Troosters; Ioannis Vogiatzis; Peter D Wagner Journal: Am J Respir Crit Care Med Date: 2014-05-01 Impact factor: 21.405
Authors: Svitlana Pasteuning-Vuhman; Johanna W Boertje-van der Meulen; Maaike van Putten; Maurice Overzier; Peter Ten Dijke; Szymon M Kiełbasa; Wibowo Arindrarto; Ron Wolterbeek; Ksenia V Lezhnina; Ivan V Ozerov; Aleksandr M Aliper; Willem M Hoogaars; Annemieke Aartsma-Rus; Cindy J M Loomans Journal: FASEB J Date: 2016-10-12 Impact factor: 5.191
Authors: Kay-Marie Lamar; Sasha Bogdanovich; Brandon B Gardner; Quan Q Gao; Tamari Miller; Judy U Earley; Michele Hadhazy; Andy H Vo; Lisa Wren; Jeffery D Molkentin; Elizabeth M McNally Journal: PLoS Genet Date: 2016-05-05 Impact factor: 5.917