Is heart failure different on the two continents (North America and Europe)?

Heart failure is increasing in both North America and Europe. Although many similarities in the disease are apparent between the two continents, differences do exist. Heart failure with preserved systolic function appears to be increasingly important on both continents, and is associated more frequently with hypertension, aging, and female sex. Treatment guidelines from the two continents show more similarities than differences, though different treatment patterns emerge. Because more patients with heart failure will be older in the future, clinical trials that include greater numbers of these patients are needed to demonstrate that therapies are as effective and safe in this population.