Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Is too much neurohormonal blockade harmful?

Literature DB >> 15075050

Is too much neurohormonal blockade harmful?

Abstract

A number of neurohormones and cytokines are activated in heart failure and their activity is related to the progression of heart failure. Inhibiting the deleterious effects of the activated sympathetic and the renin-angiotensin-aldosterone systems with b-blockers, angiotensin-converting enzyme inhibitors, and aldosterone blockers has been remarkably successful in improving the survival of patients with heart failure. However, inhibition of the other neurohormones and cytokines has not provided the expected incremental benefit, and in some cases has been deleterious, suggesting a ceiling effect of further neurohormonal blockade. This article reviews some of these studies and analyzes the possible causes of these observations.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2004 PMID： 15075050 DOI： 10.1007/s11886-004-0019-6

Source DB: PubMed Journal: Curr Cardiol Rep ISSN： 1523-3782 Impact factor: 2.931

46 in total

1. A trial of the beta-blocker bucindolol in patients with advanced chronic heart failure.

Authors: Eric J Eichhorn; Michael J Domanski; Heidi Krause-Steinrauf; Michael R Bristow; Philip W Lavori
Journal: N Engl J Med Date: 2001-05-31 Impact factor: 91.245

2. Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group.

Authors: K Swedberg; P Eneroth; J Kjekshus; L Wilhelmsen
Journal: Circulation Date: 1990-11 Impact factor: 29.690

3. Soluble TNF binding proteins modulate the negative inotropic properties of TNF-alpha in vitro.

Authors: S Kapadia; G Torre-Amione; T Yokoyama; D L Mann
Journal: Am J Physiol Date: 1995-02

4. Hemodynamic and neurohumoral effects of selective endothelin A (ET(A)) receptor blockade in chronic heart failure: the Heart Failure ET(A) Receptor Blockade Trial (HEAT).

Authors: Thomas F Lüscher; Frank Enseleit; Richard Pacher; Veselin Mitrovic; Matthias R Schulze; Roland Willenbrock; Rainer Dietz; Valentin Rousson; David Hürlimann; Sebastian Philipp; Thomas Notter; Georg Noll; Frank Ruschitzka
Journal: Circulation Date: 2002-11-19 Impact factor: 29.690

5. Outcome of patients with congestive heart failure treated with standard versus high doses of enalapril: a multicenter study. High Enalapril Dose Study Group.

Authors: J N Nanas; G Alexopoulos; M I Anastasiou-Nana; K Karidis; A Tirologos; S Zobolos; V Pirgakis; L Anthopoulos; D Sideris; S F Stamatelopoulos; S D Moulopoulos
Journal: J Am Coll Cardiol Date: 2000-12 Impact factor: 24.094

6. Inhibition of myocardial endothelin pathway improves long-term survival in heart failure.

Authors: S Sakai; T Miyauchi; M Kobayashi; I Yamaguchi; K Goto; Y Sugishita
Journal: Nature Date: 1996-11-28 Impact factor: 49.962

7. Plasma endothelin in chronic heart failure.

Authors: J J McMurray; S G Ray; I Abdullah; H J Dargie; J J Morton
Journal: Circulation Date: 1992-04 Impact factor: 29.690

8. Adrenergic effects on the biology of the adult mammalian cardiocyte.

Authors: D L Mann; R L Kent; B Parsons; G Cooper
Journal: Circulation Date: 1992-02 Impact factor: 29.690

9. Contribution of endogenous generation of endothelin-1 to basal vascular tone.

Authors: W G Haynes; D J Webb
Journal: Lancet Date: 1994-09-24 Impact factor: 79.321

10. Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both.

Authors: Marc A Pfeffer; John J V McMurray; Eric J Velazquez; Jean-Lucien Rouleau; Lars Køber; Aldo P Maggioni; Scott D Solomon; Karl Swedberg; Frans Van de Werf; Harvey White; Jeffrey D Leimberger; Marc Henis; Susan Edwards; Steven Zelenkofske; Mary Ann Sellers; Robert M Califf
Journal: N Engl J Med Date: 2003-11-10 Impact factor: 91.245

2 in total

Review 1. Predicting survival in heart failure.

Authors: Viorel G Florea; Inder S Anand
Journal: Curr Cardiol Rep Date: 2007-05 Impact factor: 2.931

2. Absence of Cardiac Benefit with Early Combination ACE Inhibitor and Beta Blocker Treatment in mdx Mice.

Authors: Alison Blain; Elizabeth Greally; Steven H Laval; Andrew M Blamire; Guy A MacGowan; Volker W Straub
Journal: J Cardiovasc Transl Res Date: 2015-04-21 Impact factor: 4.132

2 in total