BACKGROUND AND PURPOSE: Animal studies showed that human albumin therapy is strongly neuroprotective in focal ischemia. The aim of our study was to determine if relatively high serum albumin level is associated with decreased risk of poor outcome in ischemic stroke patients. METHODS: Seven hundred fifty-nine consecutive patients with acute ischemic stroke were included. Functional outcome was measured 3 months after stroke using modified Rankin Scale (mRS). Poor outcome was defined as mRS >3 or death. Serum albumin level was measured within 36 hours after stroke onset. RESULTS: Patients with poor outcome had significantly lower serum albumin level than patients with nonpoor outcome (34.1+/-7.4 versus 36.8+/-6.7 g/L). On logistic regression analysis, serum albumin level remained independent predictor of poor outcome (odds ratio [OR]: 0.43; 95% confidence interval [CI]: 0.26 to 0.70). CONCLUSIONS: Relatively high serum albumin level in acute stroke patients decreases the risk of poor outcome.
BACKGROUND AND PURPOSE: Animal studies showed that humanalbumin therapy is strongly neuroprotective in focal ischemia. The aim of our study was to determine if relatively high serum albumin level is associated with decreased risk of poor outcome in ischemic strokepatients. METHODS: Seven hundred fifty-nine consecutive patients with acute ischemic stroke were included. Functional outcome was measured 3 months after stroke using modified Rankin Scale (mRS). Poor outcome was defined as mRS >3 or death. Serum albumin level was measured within 36 hours after stroke onset. RESULTS:Patients with poor outcome had significantly lower serum albumin level than patients with nonpoor outcome (34.1+/-7.4 versus 36.8+/-6.7 g/L). On logistic regression analysis, serum albumin level remained independent predictor of poor outcome (odds ratio [OR]: 0.43; 95% confidence interval [CI]: 0.26 to 0.70). CONCLUSIONS: Relatively high serum albumin level in acute strokepatients decreases the risk of poor outcome.
Authors: Raymond C S Seet; Erle C H Lim; Y H Chan; Bernard P L Chan; Amy M L Quek; Benjamin K C Ong Journal: Neurol Sci Date: 2009-04-22 Impact factor: 3.307
Authors: Andrea Morotti; Sandro Marini; Umme K Lena; Katherine Crawford; Kristin Schwab; Christina Kourkoulis; Alison M Ayres; M Edip Gurol; Anand Viswanathan; Steven M Greenberg; Christopher D Anderson; Jonathan Rosand; Joshua N Goldstein Journal: J Neurol Date: 2017-03-10 Impact factor: 4.849