BACKGROUND AND PURPOSE: Calcified arterial plaque has been proposed as a subclinical marker of atherosclerosis. We compared it to a well-validated surrogate--carotid intimal medial thickness (IMT). METHODS: Calcified arterial plaque was measured in 2 vascular beds (coronary and carotid) by computed tomography, and common carotid artery IMT was measured by B-mode ultrasonography, in 438 participants. RESULTS: Calcium was positively associated with IMT (r=0.36 for coronary and r=0.45 for carotid, both P<0.0001). Correlations were attenuated with adjustment for age, sex, and diabetes. CONCLUSIONS: Calcified plaque in the coronary and carotid arteries is moderately associated with subclinical atherosclerosis.
BACKGROUND AND PURPOSE: Calcified arterial plaque has been proposed as a subclinical marker of atherosclerosis. We compared it to a well-validated surrogate--carotid intimal medial thickness (IMT). METHODS: Calcified arterial plaque was measured in 2 vascular beds (coronary and carotid) by computed tomography, and common carotid artery IMT was measured by B-mode ultrasonography, in 438 participants. RESULTS:Calcium was positively associated with IMT (r=0.36 for coronary and r=0.45 for carotid, both P<0.0001). Correlations were attenuated with adjustment for age, sex, and diabetes. CONCLUSIONS: Calcified plaque in the coronary and carotid arteries is moderately associated with subclinical atherosclerosis.
Authors: D W Bowden; A B Lehtinen; J T Ziegler; M E Rudock; J Xu; L E Wagenknecht; D M Herrington; S S Rich; B I Freedman; J J Carr; C D Langefeld Journal: Ann Hum Genet Date: 2008-04-29 Impact factor: 1.670
Authors: Aiman El-Saed; Akira Sekikawa; Daniel Edmundowicz; Rhobert W Evans; Kim Sutton-Tyrrell; Takashi Kadowaki; Jina Choo; Tomoko Takamiya; Lewis H Kuller Journal: Atherosclerosis Date: 2007-03-09 Impact factor: 5.162
Authors: Ryan L McKimmie; Kurt R Daniel; J Jeffrey Carr; Donald W Bowden; Barry I Freedman; Thomas C Register; Fang-Chi Hsu; Kurt K Lohman; Richard B Weinberg; Lynne E Wagenknecht Journal: Am J Gastroenterol Date: 2008-10-03 Impact factor: 10.864
Authors: Junichiro Takasu; Matthew J Budoff; Ronit Katz; Juan J Rivera; Kevin D O'Brien; David M Shavelle; Jeffrey L Probstfield; Daniel O'Leary; Khurram Nasir Journal: Atherosclerosis Date: 2009-09-15 Impact factor: 5.162
Authors: Kathryn P Burdon; Megan E Rudock; Allison B Lehtinen; Carl D Langefeld; Donald W Bowden; Thomas C Register; Yongmei Liu; Barry I Freedman; J Jeffrey Carr; Catherine C Hedrick; Stephen S Rich Journal: Mediators Inflamm Date: 2010-05-31 Impact factor: 4.711
Authors: Aaron R Folsom; Richard A Kronmal; Robert C Detrano; Daniel H O'Leary; Diane E Bild; David A Bluemke; Matthew J Budoff; Kiang Liu; Steven Shea; Moyses Szklo; Russell P Tracy; Karol E Watson; Gregory L Burke Journal: Arch Intern Med Date: 2008-06-23
Authors: Kathryn P Burdon; Allison B Lehtinen; Carl D Langefeld; J Jeffrey Carr; Stephen S Rich; Barry I Freedman; David Herrington; Donald W Bowden Journal: Diab Vasc Dis Res Date: 2008-06 Impact factor: 3.291
Authors: Joshua R Lewis; John T Schousboe; Wai H Lim; Germaine Wong; Kun Zhu; Ee M Lim; Kevin E Wilson; Peter L Thompson; Douglas P Kiel; Richard L Prince Journal: Arterioscler Thromb Vasc Biol Date: 2015-11-24 Impact factor: 8.311
Authors: Jasmin Divers; Lynne E Wagenknecht; Donald W Bowden; J Jeffrey Carr; R Caresse Hightower; Jianzhao Xu; Carl D Langefeld; Barry I Freedman Journal: Diabetes Care Date: 2009-10-13 Impact factor: 19.112