OBJECTIVES: To estimate the prostate cancer screening parameters in a population-based study of African-Caribbean men from the Island of Tobago. METHODS: A total of 2582 men aged 40 to 79 years (50% of all Tobago men in this age group) were screened using both serum prostate-specific antigen (PSA) and digital rectal examination (DRE). Men with an elevated PSA level (4 ng/mL or greater) or abnormal DRE findings were referred for ultrasound-guided sextant biopsy. RESULTS: The screening results for one or both tests were abnormal in 32% of men. The prevalence of prostate cancer was 10.7 of 100 screened men. The positive predictive value for PSA was 56% compared with 39% for DRE. The positive predictive value for PSA ranged from 6% for those aged 40 to 49 years to 59% for those aged 70 to 79 years. The sensitivity was 71% and the specificity 86% for DRE. The sensitivity for PSA was 80%. The sensitivity was low among men aged 40 to 49 years (20%) and 50 to 59 years (66%). The specificity for PSA declined across age groups from 98% for those aged 40 to 49 years to 70% for those 70 to 79 years. CONCLUSIONS: The screening parameters in this African-Caribbean population were similar to the sparse data available from other populations of African descent. The screening was highly efficacious, with a positive predictive value of 56% for an elevated PSA level and 40% for an elevated PSA level and/or abnormal DRE findings.
OBJECTIVES: To estimate the prostate cancer screening parameters in a population-based study of African-Caribbean men from the Island of Tobago. METHODS: A total of 2582 men aged 40 to 79 years (50% of all Tobago men in this age group) were screened using both serum prostate-specific antigen (PSA) and digital rectal examination (DRE). Men with an elevated PSA level (4 ng/mL or greater) or abnormal DRE findings were referred for ultrasound-guided sextant biopsy. RESULTS: The screening results for one or both tests were abnormal in 32% of men. The prevalence of prostate cancer was 10.7 of 100 screened men. The positive predictive value for PSA was 56% compared with 39% for DRE. The positive predictive value for PSA ranged from 6% for those aged 40 to 49 years to 59% for those aged 70 to 79 years. The sensitivity was 71% and the specificity 86% for DRE. The sensitivity for PSA was 80%. The sensitivity was low among men aged 40 to 49 years (20%) and 50 to 59 years (66%). The specificity for PSA declined across age groups from 98% for those aged 40 to 49 years to 70% for those 70 to 79 years. CONCLUSIONS: The screening parameters in this African-Caribbean population were similar to the sparse data available from other populations of African descent. The screening was highly efficacious, with a positive predictive value of 56% for an elevated PSA level and 40% for an elevated PSA level and/or abnormal DRE findings.
Authors: Folakemi T Odedina; Daohai Yu; Titilola O Akinremi; R Renee Reams; Matthew L Freedman; Nagi Kumar Journal: J Immigr Minor Health Date: 2008-12-04
Authors: D M Mandal; O Sartor; S L Halton; D E Mercante; J E Bailey-Wilson; W Rayford Journal: Prostate Cancer Prostatic Dis Date: 2008-02-12 Impact factor: 5.554
Authors: Alicia C McDonald; Frank J Jenkins; Clareann H Bunker; John W Wilson; Alan L Patrick; Joel L Weissfeld Journal: Infect Agent Cancer Date: 2011-12-07 Impact factor: 2.965
Authors: Guru Rajesh Jammy; Robert M Boudreau; Tushar Singh; Pawan Kumar Sharma; Kristine Ensrud; Joseph M Zmuda; P S Reddy; Anne B Newman; Jane A Cauley Journal: Arch Osteoporos Date: 2018-05-22 Impact factor: 2.617
Authors: Camille C Ragin; Emanuela Taioli; Norma McFarlane-Anderson; Gordon Avery; Franklyn Bennett; Adelia Bovell-Benjamin; Angela Brown Thompson; Agatha Carrington; Lydia Campbell-Everett; Jacqueline Ford; Anselm Hennis; Maria Jackson; Sandra Lake; M Cristina Leske; Carol Magai; Barbara Nemesure; Alfred Neugut; Folakemi Odedina; Michael Okobia; Alan Patrick; Wallis Best Plummer; R Renee Reams; Robin Roberts; Sharaneen Scott-Hastings; Sangita Sharma; Victor Wheeler; Suh-Yuh Wu; Clareann Bunker Journal: Infect Agent Cancer Date: 2007-09-24 Impact factor: 2.965
Authors: Titilola O Akinremi; Frank Chinegwundoh; Robin Roberts; Daohai Yu; R Renee Reams; Matthew L Freedman; Brian Rivers; B Lee Green; Folakemi T Odedina; Nagi Kumar Journal: Infect Agent Cancer Date: 2009-02-10 Impact factor: 2.965