| Literature DB >> 15072846 |
Eliana Cabrera1, Hugo Cerecetto, Mercedes González, Dinorah Gambino, Pabla Noblia, Lucía Otero, Beatriz Parajón-Costa, Atilio Anzellotti, Roberto Sánchez-Delgado, Amaia Azqueta, Adela López de Ceráin, Antonio Monge.
Abstract
Complexes of the type [Ru(II)Cl(2)(DMSO)(2)L], where L are 5-nitrofurylsemicarbazone derivatives, were prepared in an effort to combine the potential anti-tumor activity of the metal and the free ligands. The new complexes are excellent DNA binding agents for calf thymus DNA. So, their in vitro anti-tumor activity was tested in cellular models and the complexes were found to be non-cytotoxic on the tumor cell lines assayed, neither in aerobic conditions nor in the bio-reductive assay performed. Redox behavior, lipophilicity and stability were studied in order to explain the lack of cellular cytotoxic effects. The complexes resulted 10-100 times more hydrophilic than the parent ligands thus the bio-activity of these compounds would be compromised by their inadequate lipophilic properties.Entities:
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Year: 2004 PMID： 15072846 DOI： 10.1016/j.ejmech.2004.01.002
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514