Literature DB >> 15072554

Phosphatidylserine receptor cooperates with high-density lipoprotein receptor in recognition of apoptotic cells by thymic nurse cells.

W M Cao1, K Murao, H Imachi, C Hiramine, H Abe, X Yu, H Dobashi, N C W Wong, J Takahara, T Ishida.   

Abstract

The thymus contains many apoptotic cells that arise from the process of positive and negative selection. Both thymic macrophages and thymic nurse cells/nursing thymic epithelial cells (nursing TECs), non-professional phagocytes, recognize and ingest apoptotic cells without inflammation or tissue damage. Previously we reported that human scavenger receptor class B (SR-B1) is involved in recognition of apoptotic thymocytes by nursing TECs. In this study, we examined the expression and role of a phosphatidylserine receptor (PSR). This receptor is believed to participate in the clearance of apoptotic cells. PSR was strongly expressed in nursing TECs. Transforming growth factor-beta augmented the expression of PSR leading to enhanced binding of apoptotic cells to nursing TECs. In nursing TECs, suppressed expression of human SR-B1 with anti-PSR antibody decreased binding of apoptotic thymocytes to nursing TECs. Our results suggest that both PSR and SR-B1 are expressed in nursing TECs and these receptors appear to play a major role in the clearance of apoptotic cells from the thymus.

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Year:  2004        PMID： 15072554     DOI： 10.1677/jme.0.0320497

Source DB:  PubMed          Journal:  J Mol Endocrinol        ISSN： 0952-5041            Impact factor:   5.098


  8 in total

Review 1.  The macrophage and the apoptotic cell: an innate immune interaction viewed simplistically?

Authors:  Christopher D Gregory; Andrew Devitt
Journal:  Immunology       Date:  2004-09       Impact factor: 7.397

Review 2.  In life there is death: How epithelial tissue barriers are preserved despite the challenge of apoptosis.

Authors:  Kinga Duszyc; Guillermo A Gomez; Kate Schroder; Matthew J Sweet; Alpha S Yap
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Review 3.  Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology.

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Journal:  Immunity       Date:  2019-05-21       Impact factor: 31.745

4.  Microvascular endothelial cells express a phosphatidylserine receptor: a functionally active receptor for phosphatidylserine-positive erythrocytes.

Authors:  B N Yamaja Setty; Suhita Gayen Betal
Journal:  Blood       Date:  2007-10-02       Impact factor: 22.113

5.  Fatty acid-binding protein 4 (FABP4) and FABP5 modulate cytokine production in the mouse thymic epithelial cells.

Authors:  Yasuhiro Adachi; Sumie Hiramatsu; Nobuko Tokuda; Kazem Sharifi; Majid Ebrahimi; Ariful Islam; Yoshiteru Kagawa; Linda Koshy Vaidyan; Tomoo Sawada; Kimikazu Hamano; Yuji Owada
Journal:  Histochem Cell Biol       Date:  2012-05-15       Impact factor: 4.304

Review 6.  Tyro3 receptor tyrosine kinases in the heterogeneity of apoptotic cell uptake.

Authors:  Jeffrey L Curtis; Jill C Todt; Bin Hu; John J Osterholzer; Christine M Freeman
Journal:  Front Biosci (Landmark Ed)       Date:  2009-01-01

Review 7.  Modeling cell-in-cell structure into its biological significance.

Authors:  M-f He; S Wang; Y Wang; X-n Wang
Journal:  Cell Death Dis       Date:  2013-05-16       Impact factor: 8.469

8.  The N-terminus of CD14 acts to bind apoptotic cells and confers rapid-tethering capabilities on non-myeloid cells.

Authors:  Leanne Thomas; Anne Bielemeier; Peter A Lambert; Richard P Darveau; Lindsay J Marshall; Andrew Devitt
Journal:  PLoS One       Date:  2013-07-30       Impact factor: 3.240
  8 in total

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