| Literature DB >> 15072452 |
L K Csatary1, G Gosztonyi, J Szeberenyi, Z Fabian, V Liszka, B Bodey, C M Csatary.
Abstract
Application of virus therapy to treat human neoplasms has over a three decade history. MTH-68/H, a live attenuated oncolytic viral strain of the Newcastle disease virus, is one of the viruses used in the treatment of different malignancies. Here we report on the administration of MTH-68/H to patients with glioblastoma multiforme, the most common and most aggressive neuroectodermal neoplasm with a poor prognosis, averaging six months to a year. Four cases of advanced high-grade glioma were treated with MTH-68/H after the conventional modalities of anti-neoplastic therapies had failed. This treatment resulted in survival rates of 5-9 years, with each patient still living today. Against all odds, each patient resumed a lifestyle that resembles their previous daily routines and enjoys a good quality of life, Each of these patients has regularly received MTH-68/H as their sole form of onco-therapy for a number of years now without interruption.Entities:
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Year: 2004 PMID： 15072452 DOI： 10.1023/b:neon.0000021735.85511.05
Source DB: PubMed Journal: J Neurooncol ISSN： 0167-594X Impact factor: 4.130