Literature DB >> 15070989

Phenotypic and genetic characterization of a unique variant of serogroup C ET-15 meningococci (with the antigenic formula C:2a:P1.7,1) causing invasive meningococcal disease in Quebec, Canada.

Raymond S W Tsang1, Chao Ming Tsai, Peixuan Zhu, Louise Ringuette, Manon Lorange, Dennis K S Law.   

Abstract

Serogroup C Neisseria meningitidis belonging to the electrophoretic type (ET) ET-15, a variant of ET-37, is endemic in Canada. Like other serogroup C ET-37 meningococci, the endemic ET-15 strains are usually found to carry the serotype and serosubtype antigens of 2a:P1.5,2. In 2001, a sudden increase in the number of cases of serogroup C meningococcal disease in Quebec, Canada, was caused by an antigenic variant of the ET-15 strain. This antigenic variant carries the unique serosubtype marker of P1.7,1. Strains of C:2a:P1.7,1 meningococci were not isolated in Canada in large numbers prior to 2001, and the characteristics of these meningococcal strains linked to an outbreak in Quebec, Canada, are described in the present study.

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Year:  2004        PMID： 15070989      PMCID： PMC387618          DOI： 10.1128/JCM.42.4.1460-1465.2004

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  34 in total

1.  The panmictic nature of Neisseria meningitidis serogroup B during a period of endemic disease in Canada.

Authors:  F E Ashton; D A Caugant
Journal:  Can J Microbiol       Date:  2001-04       Impact factor: 2.419

2.  Role of horizontal genetic exchange in the antigenic variation of the class 1 outer membrane protein of Neisseria meningitidis.

Authors:  I M Feavers; A B Heath; J A Bygraves; M C Maiden
Journal:  Mol Microbiol       Date:  1992-02       Impact factor: 3.501

3.  Distribution of serogroups of Neisseria meningitidis and antigenic characterization of serogroup Y meningococci in Canada, January 1, 1999 to June 30, 2001.

Authors:  Raymond Sw Tsang; Susan G Squires; Wendell D Zollinger; Fraser E Ashton
Journal:  Can J Infect Dis       Date:  2002-11

4.  A cluster of Neisseria meningitidis cases in Quebec, January 1991.

Authors:  P Guilmette; B Fournier; Y Robert
Journal:  Can Dis Wkly Rep       Date:  1991-12-28

5.  Meningococcal infections in Quebec--1991-92.

Authors:  P Lavigne; N Boulianne; C Fortin; H Naccache; M Douville-Fradet
Journal:  Can Commun Dis Rep       Date:  1992-08-14

6.  The changing epidemiology of invasive meningococcal disease in Canada, 1985 through 1992. Emergence of a virulent clone of Neisseria meningitidis.

Authors:  C M Whalen; J C Hockin; A Ryan; F Ashton
Journal:  JAMA       Date:  1995-02-01       Impact factor: 56.272

7.  Characterization of Neisseria meningitidis strains isolated from invasive meningococcal disease cases in Canada in 2001.

Authors:  R S W Tsang; S G Squires; T W S Tam
Journal:  Can J Microbiol       Date:  2003-10       Impact factor: 2.419

8.  Proposed standardization of Neisseria meningitidis PorA variable-region typing nomenclature.

Authors:  C T Sacchi; A P Lemos; M E Brandt; A M Whitney; C E Melles; C A Solari; C E Frasch; L W Mayer
Journal:  Clin Diagn Lab Immunol       Date:  1998-11

9.  Emergence of a virulent clone of Neisseria meningitidis serotype 2a that is associated with meningococcal group C disease in Canada.

Authors:  F E Ashton; J A Ryan; A Borczyk; D A Caugant; L Mancino; D Huang
Journal:  J Clin Microbiol       Date:  1991-11       Impact factor: 5.948

10.  Outbreak of Neisseria meningitidis, Edmonton, Alberta, Canada.

Authors:  Gregory J Tyrrell; Linda Chui; Marcia Johnson; Nicholas Chang; Robert P Rennie; James A Talbot
Journal:  Emerg Infect Dis       Date:  2002-05       Impact factor: 6.883
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  9 in total

1.  DNA Sequence analysis of the PorB protein of nonserotypeable serogroup C ET-15 meningococci suggests a potential mutational hot spot on their serotype antigens.

Authors:  Dennis K S Law; Averil M Henderson; Raymond S W Tsang
Journal:  J Clin Microbiol       Date:  2004-06       Impact factor: 5.948

2.  Genetic and antigenic analysis of invasive serogroup C Neisseria meningitidis in Canada: A decrease in the electrophoretic type (ET)-15 clonal type and an increase in the proportion of isolates belonging to the ET-37 (but not ET-15) clonal type during the period from 2002 to 2009.

Authors:  Jianwei Zhou; Frances Jamieson; Sharon Dolman; Linda Mn Hoang; Prasad Rawte; Raymond Sw Tsang
Journal:  Can J Infect Dis Med Microbiol       Date:  2012       Impact factor: 2.471

3.  Analysis of phenotypic variants of the serogroup C ET-15 clone of Neisseria meningitidis by pulsed-field gel electrophoresis.

Authors:  Marissa L Cameron; Raymond S W Tsang
Journal:  J Clin Microbiol       Date:  2007-05-09       Impact factor: 5.948

4.  Invasive meningococcal disease in Quebec, Canada, due to an emerging clone of ST-269 serogroup B meningococci with serotype antigen 17 and serosubtype antigen P1.19 (B:17:P1.19).

Authors:  Dennis K S Law; Manon Lorange; Louise Ringuette; Réjean Dion; Michel Giguère; Averil M Henderson; Jan Stoltz; Wendell D Zollinger; Philippe De Wals; Raymond S W Tsang
Journal:  J Clin Microbiol       Date:  2006-08       Impact factor: 5.948

5.  Meningococcal disease: shifting epidemiology and genetic mechanisms that may contribute to serogroup C virulence.

Authors:  Jessica R Macneil; Jennifer D Thomas; Amanda C Cohn
Journal:  Curr Infect Dis Rep       Date:  2011-08       Impact factor: 3.725

6.  Invasive serogroup B Neisseria meningitidis in Quebec, Canada, 2003 to 2010: persistence of the ST-269 clone since it first emerged in 2003.

Authors:  Jianwei Zhou; Brigitte Lefebvre; Saul Deng; Rodica Gilca; Genevieve Deceuninck; Dennis K S Law; Philippe De Wals; Raymond S W Tsang
Journal:  J Clin Microbiol       Date:  2012-02-15       Impact factor: 5.948

7.  Characterisation of Neisseria meningitidis cc11/ET-15 variant by whole genome sequencing.

Authors:  Debora Ribeiro de Souza Santos; Kayo Bianco; Maysa Beatriz Mandetta Clementino; Alberto Martín Rivera Dávila; Ivano de Filippis
Journal:  Mem Inst Oswaldo Cruz       Date:  2022-10-07       Impact factor: 2.747

8.  The changing epidemiology of meningococcal disease in Quebec, Canada, 1991-2011: potential implications of emergence of new strains.

Authors:  Rodica Gilca; Geneviève Deceuninck; Brigitte Lefebvre; Raymond Tsang; Rachid Amini; Vladimir Gilca; Monique Douville-Fradet; France Markowski; Philippe De Wals
Journal:  PLoS One       Date:  2012-11-29       Impact factor: 3.240

9.  A generic mechanism in Neisseria meningitidis for enhanced resistance against bactericidal antibodies.

Authors:  Maria Jose Uria; Qian Zhang; Yanwen Li; Angel Chan; Rachel M Exley; Bridget Gollan; Hannah Chan; Ian Feavers; Andy Yarwood; Raquel Abad; Ray Borrow; Roland A Fleck; Barbara Mulloy; Julio A Vazquez; Christoph M Tang
Journal:  J Exp Med       Date:  2008-05-26       Impact factor: 14.307
  9 in total

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