| Literature DB >> 15070182 |
M A Rasadah1, S Khozirah, A A Aznie, M M Nik.
Abstract
The anti-inflammatory activity of the stem extracts of Sandoricum koetjape was investigated on topical administration using the TPA (tetradecanoylphorbol acetate)-induced mouse ear inflammation model. Bioassay-guided chromatographic fractionation of active fractions led to the isolation 3-oxo-12-oleanen-29-oic acid and katonic acid as the bioactive principles responsible for the anti-inflammatory acitivity. The percentage of inhibition exhibited by 3-oxo-12-oleanen-29-oic acid was almost equivalent to indomethacin.Entities:
Mesh:
Substances:
Year: 2004 PMID: 15070182 DOI: 10.1078/0944-7113-00339
Source DB: PubMed Journal: Phytomedicine ISSN: 0944-7113 Impact factor: 5.340