Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Knock-down of the 37-kDa/67-kDa laminin receptor in mouse brain by transgenic expression of specific antisense LRP RNA.

Literature DB >> 15070079

Knock-down of the 37-kDa/67-kDa laminin receptor in mouse brain by transgenic expression of specific antisense LRP RNA.

Christoph Leucht¹, Karen Vana, Ingrid Renner-Müller, Dominique Dormont, Corinne Ida Lasmézas, Eckhard Wolf, Stefan Weiss.

Abstract

The 37-kDa/67-kDa laminin receptor (LRP/LR) plays a major role in the propagation of PrPSc, the abnormal form of the prion protein. In order to ablate the expression of LRP/LR in mouse brain we generated transgenic mice ectopically expressing antisense LRP RNA in the brain under control of the neuron-specific enolase (NSE) promoter. Hemizygous transgenic mice TgN(NSEasLRP)2 showed a significant reduction of LRP/LR protein levels in hippocampal and cerebellar brain regions. These mice might act as powerful tools to investigate the role of the laminin receptor in scrapie pathogenesis.

Entities: Gene Species

Mesh：

Substances：

Year: 2004 PMID： 15070079 DOI： 10.1023/b:trag.0000017177.35197.89

Source DB: PubMed Journal: Transgenic Res ISSN： 0962-8819 Impact factor: 2.788

13 in total

1. Identification of interaction domains of the prion protein with its 37-kDa/67-kDa laminin receptor.

Authors: C Hundt; J M Peyrin; S Haïk; S Gauczynski; C Leucht; R Rieger; M L Riley; J P Deslys; D Dormont; C I Lasmézas; S Weiss
Journal: EMBO J Date: 2001-11-01 Impact factor: 11.598

Review 2. Interaction of prion proteins with cell surface receptors, molecular chaperones, and other molecules.

Authors: S Gauczynski; C Hundt; C Leucht; S Weiss
Journal: Adv Protein Chem Date: 2001

3. Scrapie prion rod formation in vitro requires both detergent extraction and limited proteolysis.

Authors: M P McKinley; R K Meyer; L Kenaga; F Rahbar; R Cotter; A Serban; S B Prusiner
Journal: J Virol Date: 1991-03 Impact factor: 5.103

4. Transgenic mice expressing beta-galactosidase in mature neurons under neuron-specific enolase promoter control.

Authors: S Forss-Petter; P E Danielson; S Catsicas; E Battenberg; J Price; M Nerenberg; J G Sutcliffe
Journal: Neuron Date: 1990-08 Impact factor: 17.173

5. Distribution of experimentally induced scrapie lesions in the brain.

Authors: H Fraser; A G Dickinson
Journal: Nature Date: 1967-12-30 Impact factor: 49.962

6. Strain specific and common pathogenic events in murine models of scrapie and bovine spongiform encephalopathy.

Authors: C I Lasmézas; J P Deslys; R Demaimay; K T Adjou; J J Hauw; D Dormont
Journal: J Gen Virol Date: 1996-07 Impact factor: 3.891

7. The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells.

Authors: R Rieger; F Edenhofer; C I Lasmézas; S Weiss
Journal: Nat Med Date: 1997-12 Impact factor: 53.440

8. The 37 kDa/67 kDa laminin receptor is required for PrP(Sc) propagation in scrapie-infected neuronal cells.

Authors: Christoph Leucht; Steve Simoneau; Clémence Rey; Karen Vana; Roman Rieger; Corinne Ida Lasmézas; Stefan Weiss
Journal: EMBO Rep Date: 2003-03 Impact factor: 8.807

Review 9. Prions.

Authors: S B Prusiner
Journal: Proc Natl Acad Sci U S A Date: 1998-11-10 Impact factor: 11.205

10. Impaired type II glucocorticoid-receptor function in mice bearing antisense RNA transgene.

Authors: M C Pepin; F Pothier; N Barden
Journal: Nature Date: 1992-02-20 Impact factor: 49.962

6 in total

Review 1. Therapies for human prion diseases.

Authors: Peter K Panegyres; Elizabeth Armari
Journal: Am J Neurodegener Dis Date: 2013-09-18