Alexandre Boyer1, Karim Chadda, Amar Salah, Guy Bonmarchand. 1. Service de Réanimation Médicale, Hôpital Charles Nicolle, Centre Hospitalier Universitaire de Rouen, 1 rue de Germont, 76031 Rouen, France. alexandre.boyer@chu-bordeaux.fr
Abstract
OBJECTIVE: To report on the development and treatment of thrombotic microangiopathy, an atypical cause of acute renal failure in patients with acute pancreatitis. DESIGN: Case reports. SETTING: A 21-bed medical intensive care unit at an university hospital. PATIENTS: Two men with acute pancreatitis presented with acute renal failure, neurological manifestations, haemolytic anaemia and thrombocytopenia. Both patients required intensive care. MEASUREMENTS: Fragmented red cell count; levels of haptoglobin, amylase and lipase; serological testing for Escherichia Coli O157; computed tomography of the abdomen. MAIN RESULTS: The patients' courses were rapidly favourable after daily plasma exchange. A review of the existing medical literature was also undertaken. CONCLUSION: As thrombotic microangiopathy may be life-threatening without administration of fresh frozen plasma or plasma exchange, physicians should consider this disease as a possible cause of acute renal failure in patients with acute pancreatitis.
OBJECTIVE: To report on the development and treatment of thrombotic microangiopathy, an atypical cause of acute renal failure in patients with acute pancreatitis. DESIGN: Case reports. SETTING: A 21-bed medical intensive care unit at an university hospital. PATIENTS: Two men with acute pancreatitis presented with acute renal failure, neurological manifestations, haemolytic anaemia and thrombocytopenia. Both patients required intensive care. MEASUREMENTS: Fragmented red cell count; levels of haptoglobin, amylase and lipase; serological testing for Escherichia Coli O157; computed tomography of the abdomen. MAIN RESULTS: The patients' courses were rapidly favourable after daily plasma exchange. A review of the existing medical literature was also undertaken. CONCLUSION: As thrombotic microangiopathy may be life-threatening without administration of fresh frozen plasma or plasma exchange, physicians should consider this disease as a possible cause of acute renal failure in patients with acute pancreatitis.
Authors: Jin J Bong; Basil J Ammori; Michael J McMahon; Ajay Kumar; John H Turney; Derek R Norfolk Journal: Pancreas Date: 2002-07 Impact factor: 3.327
Authors: A Cerveró Marti; J Martin; A Pérez-Payá; J Sanchis; P Canelles; J García-Marco; M Sanchez Journal: Ann Hematol Date: 1992-11 Impact factor: 3.673