| Literature DB >> 15068852 |
Larisa I Karpenko1, Nadezhda A Nekrasova, Alexander A Ilyichev, Leonid R Lebedev, George M Ignatyev, Alexander P Agafonov, Boris N Zaitsev, Pavel A Belavin, Sergei V Seregin, Nadezhda K Danilyuk, Irina N Babkina, Sergei I Bazhan.
Abstract
Two systems have been examined for delivery of DNA-vaccine encoding a HIV-1 polyepitope CTL-immunogen (TCI). One is intended for i.m. injection and is in the form of an artificial virus like particle containing eukaryotic expression plasmid pcDNA-TCI encapsulated within a spermidine-polyglucin conjugate. The other is intended for mucosal immunization and is based on attenuated Salmonella typhimurium strain 7207, which can deliver pcDNA-TCI directly into professional antigen-presenting cells (APC). After immunization, the artificial VLP and recombinant Salmonella induced an enhanced HIV specific serum antibody, proliferative and CTL responses compared to those induced by naked pcDNA-TCI. The most significant responses were produced when pcDNA-TCI was delivered by Salmonella.Entities:
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Year: 2004 PMID： 15068852 DOI： 10.1016/j.vaccine.2003.09.050
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641