A W E Weverling-Rijnsburger1, G J Blauw, A E Meinders. 1. Department of General Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands. a.w.e.weverling-rijnsburger@lumc.nl
Abstract
OBJECTIVE: This study was initiated to examine the effect of cholesterol-lowering therapy with 40 mg atorvastatin on vascular function in healthy old and young men. METHODS: We selected healthy normolipidaemic, elderly subjects (n = 8, mean age 80.1 years) and young subjects (n = 7, mean age 21.8 years). All had a normal electrocardiograph and blood pressure, and signs or symptoms of cardiovascular disease were absent. The subjects were studied for 2 days, with 6 weeks of atorvastatin treatment in between. Forearm blood flow (FBF) was measured by computerized venous occlusion plethysmography upon intra-arterial infusion of acetylcholine (ACh; 30 and 90 ng/kg/min) and 5-hydroxytryptamine (5-HT; 0.3 and 0.9 ng/kg/min) as endothelium-dependent vasodilators, and sodium nitroprusside (SNP; 30 and 90 ng/kg/min) as an endothelium-independent vasodilator. RESULTS: At baseline, the mean absolute FBF in the elderly was 2.6 mL/min/100 mL and in the young 4.3 mL/min/100 mL tissue (P = 0.01). The mean serum total cholesterol levels were 5.2 and 3.8 mmol/L, respectively (P = 0.007). The endothelium-dependent vasodilatation induced by ACh and 5-HT was significantly lower in the elderly compared with the young (both P < 0.01), whereas the endothelium-independent vasodilatation induced by SNP was not significantly lower in the elderly compared with the young. Atorvastatin treatment decreased the serum total cholesterol level with a mean of 38 and 28% in the elderly and the young, respectively (P < 0.001). Impaired endothelium-dependent vasodilatation, however, was not modified (P > 0.65). CONCLUSIONS: Healthy old men have an impaired endothelium-dependent vascular response but this impairment is not restored by treatment with atorvastatin.
OBJECTIVE: This study was initiated to examine the effect of cholesterol-lowering therapy with 40 mg atorvastatin on vascular function in healthy old and young men. METHODS: We selected healthy normolipidaemic, elderly subjects (n = 8, mean age 80.1 years) and young subjects (n = 7, mean age 21.8 years). All had a normal electrocardiograph and blood pressure, and signs or symptoms of cardiovascular disease were absent. The subjects were studied for 2 days, with 6 weeks of atorvastatin treatment in between. Forearm blood flow (FBF) was measured by computerized venous occlusion plethysmography upon intra-arterial infusion of acetylcholine (ACh; 30 and 90 ng/kg/min) and 5-hydroxytryptamine (5-HT; 0.3 and 0.9 ng/kg/min) as endothelium-dependent vasodilators, and sodium nitroprusside (SNP; 30 and 90 ng/kg/min) as an endothelium-independent vasodilator. RESULTS: At baseline, the mean absolute FBF in the elderly was 2.6 mL/min/100 mL and in the young 4.3 mL/min/100 mL tissue (P = 0.01). The mean serum total cholesterol levels were 5.2 and 3.8 mmol/L, respectively (P = 0.007). The endothelium-dependent vasodilatation induced by ACh and 5-HT was significantly lower in the elderly compared with the young (both P < 0.01), whereas the endothelium-independent vasodilatation induced by SNP was not significantly lower in the elderly compared with the young. Atorvastatin treatment decreased the serum total cholesterol level with a mean of 38 and 28% in the elderly and the young, respectively (P < 0.001). Impaired endothelium-dependent vasodilatation, however, was not modified (P > 0.65). CONCLUSIONS: Healthy old men have an impaired endothelium-dependent vascular response but this impairment is not restored by treatment with atorvastatin.
Authors: Luciola M L Crisostomo; Carlos A M Souza; Carlos M C Mendes; Silmara R Coimbra; Desiderio Favarato; Protasio L da Luz Journal: Clinics (Sao Paulo) Date: 2008-10 Impact factor: 2.365