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Literature DB >> 15066275

Dicers at RISC; the mechanism of RNAi.

Marcel Tijsterman¹, Ronald H A Plasterk.

Abstract

The pathway of RNA interference starts when Dicer cuts dsRNA into small interfering RNAs (siRNAs) that subsequently target homologous mRNAs for destruction. microRNA processing from stem loop precursors similarly requires Dicer activity. Two papers in this issue of Cell now demonstrate that Dicer is also essential for the execution phase of RNAi and explore the distinct requirements for Dicers in the siRNA and miRNA pathways.

Entities: Gene

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Year: 2004 PMID： 15066275 DOI： 10.1016/s0092-8674(04)00293-4

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

87 in total

1. Epigenetics of heterochromatin.

Authors: Subhash C Lakhotia
Journal: J Biosci Date: 2004-09 Impact factor: 1.826

2. Discovery and characterization of novel microRNAs during endothelial differentiation of human embryonic stem cells.

Authors: Jung Ki Yoo; Jumi Kim; Seong-Jun Choi; Hye Min Noh; Young Do Kwon; Hanna Yoo; Hyo Seon Yi; Hyung Min Chung; Jin Kyeoung Kim
Journal: Stem Cells Dev Date: 2012-02-07 Impact factor: 3.272

3. siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells.

Authors: Morten Ø Andersen; Jens V Nygaard; Jorge S Burns; Merete K Raarup; Jens R Nyengaard; Cody Bünger; Flemming Besenbacher; Kenneth A Howard; Moustapha Kassem; Jørgen Kjems
Journal: Mol Ther Date: 2010-08-31 Impact factor: 11.454

9. RNA interference inhibits respiratory syncytial virus replication and disease pathogenesis without inhibiting priming of the memory immune response.

Authors: Wenliang Zhang; Ralph A Tripp
Journal: J Virol Date: 2008-09-25 Impact factor: 5.103

Review 10. RNA interference-based therapeutics for human immunodeficiency virus HIV-1 treatment: synthetic siRNA or vector-based shRNA?

Authors: Sandesh Subramanya; Sang-Soo Kim; N Manjunath; Premlata Shankar
Journal: Expert Opin Biol Ther Date: 2010-02 Impact factor: 4.388

Dicers at RISC; the mechanism of RNAi.

1. Epigenetics of heterochromatin.

2. Discovery and characterization of novel microRNAs during endothelial differentiation of human embryonic stem cells.

3. siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells.

Review 4. microRNAs in cardiovascular development.

5. GVHD and miR: good things in small packages.

6. Probing microRNAs with microarrays: tissue specificity and functional inference.

Review 7. Modulation of immune responses following solid organ transplantation by microRNA.

8. A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans.

9. RNA interference inhibits respiratory syncytial virus replication and disease pathogenesis without inhibiting priming of the memory immune response.

Review 10. RNA interference-based therapeutics for human immunodeficiency virus HIV-1 treatment: synthetic siRNA or vector-based shRNA?