Literature DB >> 15066258

The great escape; phosphorylation of Ena/VASP by PKA promotes filopodial formation.

Timothy M Gomez1, Estuardo Robles.   

Abstract

The Ena/VASP family of proteins consists of adaptor molecules that localize to subcellular sites of actin polymerization. The role of Ena/VASP proteins in the regulation of cell motility and axon outgrowth has been controversial. Recently, these proteins have been proposed to function as "anticapping" factors, which may have differential effects on filopodial versus lammelipodial actin-based protrusions. A study by Lebrand et al. in this issue of Neuron supports this model and identifies PKA as a key regulator of Ena/VASP function downstream of the chemoattractant Netrin.

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Year:  2004        PMID： 15066258     DOI： 10.1016/s0896-6273(04)00188-6

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  9 in total

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4.  Insight into bacterial virulence mechanisms against host immune response via the Yersinia pestis-human protein-protein interaction network.

Authors:  Huiying Yang; Yuehua Ke; Jian Wang; Yafang Tan; Sebenzile K Myeni; Dong Li; Qinghai Shi; Yanfeng Yan; Hui Chen; Zhaobiao Guo; Yanzhi Yuan; Xiaoming Yang; Ruifu Yang; Zongmin Du
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5.  Differentiation of the endometrial macrophage during pregnancy in the cow.

Authors:  Lilian J Oliveira; Steve McClellan; Peter J Hansen
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6.  Human axonal survival of motor neuron (a-SMN) protein stimulates axon growth, cell motility, C-C motif ligand 2 (CCL2), and insulin-like growth factor-1 (IGF1) production.

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Review 7.  Protein Kinase A in cellular migration-Niche signaling of a ubiquitous kinase.

Authors:  Kathryn V Svec; Alan K Howe
Journal:  Front Mol Biosci       Date:  2022-07-22

8.  Carbon monoxide and nitric oxide mediate cytoskeletal reorganization in microvascular cells via vasodilator-stimulated phosphoprotein phosphorylation: evidence for blunted responsiveness in diabetes.

Authors:  Sergio Li Calzi; Daniel L Purich; Kyung Hee Chang; Aqeela Afzal; Takahiko Nakagawa; Julia V Busik; Anupam Agarwal; Mark S Segal; Maria B Grant
Journal:  Diabetes       Date:  2008-06-16       Impact factor: 9.461

9.  Scutellarin Reduces Endothelium Dysfunction through the PKG-I Pathway.

Authors:  Xiaohua Du; Chen Chen; Min Zhang; Donghua Cai; Jiaqi Sun; Jian Yang; Na Hu; Congji Ma; Liyan Zhang; Jun Zhang; Weimin Yang
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  9 in total

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