Hugh C Hendrie1, Kathleen S Hall, Adesola Ogunniyi, Sujuan Gao. 1. Department of Psychiatry, Indiana University School of Medicine, Indiana University Center for Aging Research, Indianapolis 46202-2872, USA. hhendri@iupui.edu
Abstract
OBJECTIVE: To describe the construction of a disease model incorporating both genetic an environmental factors in the etiology of Alzheimer's disease (AD), using data generated from the Indianapolis-Ibadan dementia project (I-IDP). METHOD: The I-IDP is a longitudinal comparative study of the prevalence and incidence o dementia in 2 communities: elderly African Americans living in Indianapolis, Indiana, an Yoruba living in Ibadan, Nigeria. RESULTS: African Americans are more than twice as likely as Yoruba to develop AD. Possible explanations for this finding include genetic factors: the possession of the apolipoprotein E epsilon4 allele does not increase risk for AD among Yoruba but confers a sligh increase in AD risk for African Americans. As well, environmental factors may play a role: African Americans have a higher risk of vascular risk factors than do Yoruba. CONCLUSIONS: International comparative studies, particularly those involving population from developing and developed countries, offer a unique opportunity for applying new in formation regarding population genetics to traditional AD risk factor research.
OBJECTIVE: To describe the construction of a disease model incorporating both genetic an environmental factors in the etiology of Alzheimer's disease (AD), using data generated from the Indianapolis-Ibadan dementia project (I-IDP). METHOD: The I-IDP is a longitudinal comparative study of the prevalence and incidence o dementia in 2 communities: elderly African Americans living in Indianapolis, Indiana, an Yoruba living in Ibadan, Nigeria. RESULTS: African Americans are more than twice as likely as Yoruba to develop AD. Possible explanations for this finding include genetic factors: the possession of the apolipoprotein E epsilon4 allele does not increase risk for AD among Yoruba but confers a sligh increase in AD risk for African Americans. As well, environmental factors may play a role: African Americans have a higher risk of vascular risk factors than do Yoruba. CONCLUSIONS: International comparative studies, particularly those involving population from developing and developed countries, offer a unique opportunity for applying new in formation regarding population genetics to traditional AD risk factor research.
Authors: Hugh C Hendrie; Jill Murrell; Olusegun Baiyewu; Kathleen A Lane; Christianna Purnell; Adesola Ogunniyi; Frederick W Unverzagt; Kathleen Hall; Christopher M Callahan; Andrew J Saykin; Oye Gureje; Ann Hake; Tatiana Foroud; Sujuan Gao Journal: Int Psychogeriatr Date: 2014-02-24 Impact factor: 3.878
Authors: Oye Gureje; Adesola Ogunniyi; Olusegun Baiyewu; Brandon Price; Frederick W Unverzagt; Rebecca M Evans; Valerie Smith-Gamble; Kathleen A Lane; Sujuan Gao; Kathleen S Hall; Hugh C Hendrie; Jill R Murrell Journal: Ann Neurol Date: 2006-01 Impact factor: 10.422
Authors: A Ogunniyi; K S Hall; O Gureje; O Baiyewu; S Gao; F W Unverzagt; V Smith-Gamble; R E Evans; J Dickens; B S Musick; H C Hendrie Journal: Metab Brain Dis Date: 2006-07-19 Impact factor: 3.584
Authors: Jill R Murrell; Brandon Price; Kathleen A Lane; Olusegun Baiyewu; Oye Gureje; Adesola Ogunniyi; Frederick W Unverzagt; Valerie Smith-Gamble; Sujuan Gao; Hugh C Hendrie; Kathleen S Hall Journal: Arch Neurol Date: 2006-03
Authors: Hugh C Hendrie; Olusegun Baiyewu; Kathleen A Lane; Christianna Purnell; Sujuan Gao; Ann Hake; Adesola Ogunniyi; Oye Gureje; Frederick W Unverzagt; Jill Murrell; Mark A Deeg; Kathleen Hall Journal: Int Psychogeriatr Date: 2013-07-30 Impact factor: 3.878
Authors: Beatriz Marcheco Teruel; Juan J Llibre Rodríguez; Paul McKeigue; Teresa Collazo Mesa T; Evelyn Fuentes; Adolfo Valhuerdi Cepero A; Milagros A Guerra Hernandez; John R M Copeland J R M; Cleusa P Ferri; Martin J Prince Journal: BMC Med Genet Date: 2011-03-24 Impact factor: 2.103
Authors: Kurt D Christensen; J Scott Roberts; Charmaine D M Royal; Grace-Ann Fasaye; Thomas Obisesan; L Adrienne Cupples; Peter J Whitehouse; Melissa Barber Butson; Erin Linnenbringer; Norman R Relkin; Lindsay Farrer; Robert Cook-Deegan; Robert C Green Journal: Genet Med Date: 2008-03 Impact factor: 8.822