Literature DB >> 15065221

Upregulation of striatal adenosine A2A receptor mRNA in 6-hydroxydopamine-lesioned rats intermittently treated with L-DOPA.

Masahiko Tomiyama1, Tamaki Kimura, Tetsuya Maeda, Hiroyasu Tanaka, Kazuya Kannari, Masayuki Baba.   

Abstract

To determine whether the adenosine A2A receptor might play a role in L-DOPA-induced dyskinesia in Parkinson's disease, we analyzed changes in the expression of A2A receptor mRNA in response to intermittent treatment with L-DOPA in rats with dopaminergic denervation by 6-hydroxydopamine (OHDA) infusion into the medial forebrain bundle. Intermittent treatment with L-DOPA increased A2A receptor mRNA levels in the dopamine-depleted striatum of 6-OHDA-lesioned rats exhibiting behavioral sensitization to L-DOPA. These results suggest that A2A receptor activation is associated with the development of motor complications induced by L-DOPA treatment. Copyright 2004 Wiley-Liss, Inc.

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Year:  2004        PMID： 15065221     DOI： 10.1002/syn.20011

Source DB:  PubMed          Journal:  Synapse        ISSN： 0887-4476            Impact factor:   2.562


  11 in total

1.  Computer-assisted image analysis of caveolin-1 involvement in the internalization process of adenosine A2A-dopamine D2 receptor heterodimers.

Authors:  Susanna Genedani; Diego Guidolin; Giuseppina Leo; Monica Filaferro; Maria Torvinen; Amina S Woods; Kjell Fuxe; Sergi Ferré; Luigi F Agnati
Journal:  J Mol Neurosci       Date:  2005       Impact factor: 3.444

2.  Astrocytic A2A receptors: Novel targets to manage brain disorders: PS168.

Authors:  Vanessa Henriques; Nélio Gonçalves; Paula Agostinho; Rodrigo A Cunha
Journal:  Porto Biomed J       Date:  2017-09-01

3.  Striatal adenosine A(2A) receptor-mediated positron emission tomographic imaging in 6-hydroxydopamine-lesioned rats using [(18)F]-MRS5425.

Authors:  Abesh Kumar Bhattacharjee; Lixin Lang; Orit Jacobson; Bidhan Shinkre; Ying Ma; Gang Niu; William C Trenkle; Kenneth A Jacobson; Xiaoyuan Chen; Dale O Kiesewetter
Journal:  Nucl Med Biol       Date:  2011-03-30       Impact factor: 2.408

4.  Effect of adenosine A2A receptor antagonist ZM241385 on amygdala-kindled seizures and progression of amygdala kindling.

Authors:  Xiang Li; Huicong Kang; Xiaoyan Liu; Zhiguang Liu; Kai Shu; Xu Chen; Suiqiang Zhu
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2012-04-20

Review 5.  Mechanisms of induction of adenosine receptor genes and its functional significance.

Authors:  Cynthia St Hilaire; Shannon H Carroll; Hongjie Chen; Katya Ravid
Journal:  J Cell Physiol       Date:  2009-01       Impact factor: 6.384

Review 6.  Purinergic Receptors in Basal Ganglia Diseases: Shared Molecular Mechanisms between Huntington's and Parkinson's Disease.

Authors:  Talita Glaser; Roberta Andrejew; Ágatha Oliveira-Giacomelli; Deidiane Elisa Ribeiro; Lucas Bonfim Marques; Qing Ye; Wen-Jing Ren; Alexey Semyanov; Peter Illes; Yong Tang; Henning Ulrich
Journal:  Neurosci Bull       Date:  2020-10-07       Impact factor: 5.203

7.  A(2A) Receptor Antagonism and Dyskinesia in Parkinson's Disease.

Authors:  Micaela Morelli; Fabio Blandini; Nicola Simola; Robert A Hauser
Journal:  Parkinsons Dis       Date:  2012-06-17

8.  Neuroprotection by adenosine in the brain: From A(1) receptor activation to A (2A) receptor blockade.

Authors:  Rodrigo A Cunha
Journal:  Purinergic Signal       Date:  2005-03-17       Impact factor: 3.765

Review 9.  Targeting Adenosine Signaling in Parkinson's Disease: From Pharmacological to Non-pharmacological Approaches.

Authors:  Luiza R Nazario; Rosane S da Silva; Carla D Bonan
Journal:  Front Neurosci       Date:  2017-11-23       Impact factor: 4.677

Review 10.  Advances in CNS PET: the state-of-the-art for new imaging targets for pathophysiology and drug development.

Authors:  Stuart P McCluskey; Christophe Plisson; Eugenii A Rabiner; Oliver Howes
Journal:  Eur J Nucl Med Mol Imaging       Date:  2019-09-21       Impact factor: 9.236
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