Stephen Pickup1, Andrew K W Wood, Harold L Kundel. 1. Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. radiosp@oasis.rad.upenn.edu
Abstract
PURPOSE: To develop an efficient method for extracting maps of the corrected T1 from images generated using the T One by Multiple Read Out Pulses (TOMROP) sequence. MATERIALS AND METHODS: An expression is developed for the true T1 in terms of the parameters from a three-parameter fit of the TOMROP data. Solutions of gadodiamide in normal saline with concentrations of 0.0, 0.06, 0.11, 0.23, 0.46, and 0.91 mM were prepared and T1 measurements were performed using both the inversion recovery (IR) and the TOMROP methods. The TOMROP data were analyzed using the proposed technique and the results compared to those from the IR measurements. RESULTS: The T1 estimates generated from the TOMROP data using the proposed method were consistent with the IR results. However, systematic errors were observed in the T1 estimates when the repetition time was not sufficient for full recovery of axial magnetization. Relaxation times determined using the proposed method were within 1% of the spectroscopiclly determined values for T1 values in the range of 0.28-2.8 seconds when a suitable delay was employed. CONCLUSION: The proposed method of analysis was found to yield accurate T1 estimates when the assumptions used in the analysis were not violated. Copyright 2004 Wiley-Liss, Inc.
PURPOSE: To develop an efficient method for extracting maps of the corrected T1 from images generated using the T One by Multiple Read Out Pulses (TOMROP) sequence. MATERIALS AND METHODS: An expression is developed for the true T1 in terms of the parameters from a three-parameter fit of the TOMROP data. Solutions of gadodiamide in normal saline with concentrations of 0.0, 0.06, 0.11, 0.23, 0.46, and 0.91 mM were prepared and T1 measurements were performed using both the inversion recovery (IR) and the TOMROP methods. The TOMROP data were analyzed using the proposed technique and the results compared to those from the IR measurements. RESULTS: The T1 estimates generated from the TOMROP data using the proposed method were consistent with the IR results. However, systematic errors were observed in the T1 estimates when the repetition time was not sufficient for full recovery of axial magnetization. Relaxation times determined using the proposed method were within 1% of the spectroscopiclly determined values for T1 values in the range of 0.28-2.8 seconds when a suitable delay was employed. CONCLUSION: The proposed method of analysis was found to yield accurate T1 estimates when the assumptions used in the analysis were not violated. Copyright 2004 Wiley-Liss, Inc.
Authors: Hualei Zhang; Hui Qiao; Rachel S Frank; Bin Huang; Kathleen J Propert; Susan Margulies; Victor A Ferrari; Jonathan A Epstein; Rong Zhou Journal: Circ Cardiovasc Imaging Date: 2012-02-06 Impact factor: 7.792
Authors: Jianbo Cao; Stephen Pickup; Cynthia Clendenin; Barbara Blouw; Hoon Choi; David Kang; Mark Rosen; Peter J O'Dwyer; Rong Zhou Journal: Clin Cancer Res Date: 2018-12-26 Impact factor: 12.531
Authors: Michael Jerosch-Herold; David C Sheridan; Jessica D Kushner; Deirdre Nauman; Donna Burgess; Diana Dutton; Rami Alharethi; Duanxiang Li; Ray E Hershberger Journal: Am J Physiol Heart Circ Physiol Date: 2008-07-25 Impact factor: 4.733