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Literature DB >> 15064809

Genome features of Leptospira interrogans serovar Copenhageni.

A L T O Nascimento¹, S Verjovski-Almeida, M A Van Sluys, C B Monteiro-Vitorello, L E A Camargo, L A Digiampietri, R A Harstkeerl, P L Ho, M V Marques, M C Oliveira, J C Setubal, D A Haake, E A L Martins.

Abstract

We report novel features of the genome sequence of Leptospira interrogans serovar Copenhageni, a highly invasive spirochete. Leptospira species colonize a significant proportion of rodent populations worldwide and produce life-threatening infections in mammals. Genomic sequence analysis reveals the presence of a competent transport system with 13 families of genes encoding for major transporters including a three-member component efflux system compatible with the long-term survival of this organism. The leptospiral genome contains a broad array of genes encoding regulatory system, signal transduction and methyl-accepting chemotaxis proteins, reflecting the organism's ability to respond to diverse environmental stimuli. The identification of a complete set of genes encoding the enzymes for the cobalamin biosynthetic pathway and the novel coding genes related to lipopolysaccharide biosynthesis should bring new light to the study of Leptospira physiology. Genes related to toxins, lipoproteins and several surface-exposed proteins may facilitate a better understanding of the Leptospira pathogenesis and may serve as potential candidates for vaccine.

Entities: Chemical Species

Mesh：

Substances：
Bacterial Proteins

Year: 2004 PMID： 15064809 PMCID： PMC2666282 DOI： 10.1590/s0100-879x2004000400003

Source DB: PubMed Journal: Braz J Med Biol Res ISSN： 0100-879X Impact factor: 2.590

58 in total

1. Bright lights, abundant operons--fluorescence and genomic technologies advance studies of bacterial locomotion and signal transduction: review of the BLAST meeting, Cuernavaca, Mexico, 14 to 19 January 2001.

Authors: Robert B Bourret; Nyles W Charon; Ann M Stock; Ann H West
Journal: J Bacteriol Date: 2002-01 Impact factor: 3.490

2. Genome sequence of the plant pathogen Ralstonia solanacearum.

Authors: M Salanoubat; S Genin; F Artiguenave; J Gouzy; S Mangenot; M Arlat; A Billault; P Brottier; J C Camus; L Cattolico; M Chandler; N Choisne; C Claudel-Renard; S Cunnac; N Demange; C Gaspin; M Lavie; A Moisan; C Robert; W Saurin; T Schiex; P Siguier; P Thébault; M Whalen; P Wincker; M Levy; J Weissenbach; C A Boucher
Journal: Nature Date: 2002-01-31 Impact factor: 49.962

Review 3. Lipopolysaccharide endotoxins.

Authors: Christian R H Raetz; Chris Whitfield
Journal: Annu Rev Biochem Date: 2001-11-09 Impact factor: 23.643

Review 4. The bacterial replication initiator DnaA. DnaA and oriC, the bacterial mode to initiate DNA replication.

Authors: Walter Messer
Journal: FEMS Microbiol Rev Date: 2002-11 Impact factor: 16.408

5. Characterization of the leptospiral outer membrane and description of three novel leptospiral membrane proteins.

Authors: David A Haake; James Matsunaga
Journal: Infect Immun Date: 2002-09 Impact factor: 3.441

6. Role of a highly conserved bacterial protein in outer membrane protein assembly.

Authors: Romé Voulhoux; Martine P Bos; Jeroen Geurtsen; Maarten Mols; Jan Tommassen
Journal: Science Date: 2003-01-10 Impact factor: 47.728

7. Comparative analyses of the complete genome sequences of Pierce's disease and citrus variegated chlorosis strains of Xylella fastidiosa.

Authors: M A Van Sluys; M C de Oliveira; C B Monteiro-Vitorello; C Y Miyaki; L R Furlan; L E A Camargo; A C R da Silva; D H Moon; M A Takita; E G M Lemos; M A Machado; M I T Ferro; F R da Silva; M H S Goldman; G H Goldman; M V F Lemos; H El-Dorry; S M Tsai; H Carrer; D M Carraro; R C de Oliveira; L R Nunes; W J Siqueira; L L Coutinho; E T Kimura; E S Ferro; R Harakava; E E Kuramae; C L Marino; E Giglioti; I L Abreu; L M C Alves; A M do Amaral; G S Baia; S R Blanco; M S Brito; F S Cannavan; A V Celestino; A F da Cunha; R C Fenille; J A Ferro; E F Formighieri; L T Kishi; S G Leoni; A R Oliveira; V E Rosa; F T Sassaki; J A D Sena; A A de Souza; D Truffi; F Tsukumo; G M Yanai; L G Zaros; E L Civerolo; A J G Simpson; N F Almeida; J C Setubal; J P Kitajima
Journal: J Bacteriol Date: 2003-02 Impact factor: 3.490

8. A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury.

Authors: Zeljko Vujaskovic; Ines Batinic-Haberle; Zahid N Rabbani; Qin-fu Feng; Song K Kang; Ivan Spasojevic; Thaddeus V Samulski; Irwin Fridovich; Mark W Dewhirst; Mitchell S Anscher
Journal: Free Radic Biol Med Date: 2002-09-15 Impact factor: 7.376

9. An antiport mechanism for a member of the cation diffusion facilitator family: divalent cations efflux in exchange for K+ and H+.

Authors: Arthur A Guffanti; Yi Wei; Sacha V Rood; Terry A Krulwich
Journal: Mol Microbiol Date: 2002-07 Impact factor: 3.501

10. Analysis of a Leptospira interrogans locus containing DNA replication genes and a new IS, IS1502.

Authors: R L Zuerner; W M Huang
Journal: FEMS Microbiol Lett Date: 2002-10-08 Impact factor: 2.742

79 in total

1. A newly identified leptospiral adhesin mediates attachment to laminin.

Authors: Angela S Barbosa; Patricia A E Abreu; Fernanda O Neves; Marina V Atzingen; Mônica M Watanabe; Mônica L Vieira; Zenaide M Morais; Sílvio A Vasconcellos; Ana L T O Nascimento
Journal: Infect Immun Date: 2006-09-05 Impact factor: 3.441

2. Immunohistochemical and in situ hybridization studies of the liver and kidney in human leptospirosis.

Authors: T De Brito; L F Menezes; Dirce M C Lima; Silvia Lourenço; Ana Maria G Silva; V A F Alves
Journal: Virchows Arch Date: 2006-03-16 Impact factor: 4.064

3. Precipitation of iron on the surface of Leptospira interrogans is associated with mutation of the stress response metalloprotease HtpX.

Authors: Rebekah Henry; Miranda Lo; Chenai Khoo; Hailong Zhang; Reinhard I Boysen; Mathieu Picardeau; Gerald L Murray; Dieter M Bulach; Ben Adler
Journal: Appl Environ Microbiol Date: 2013-05-24 Impact factor: 4.792

4. The genome of Rhodobacter sphaeroides strain 2.4.1 encodes functional cobinamide salvaging systems of archaeal and bacterial origins.

Authors: Michael J Gray; Norbert K Tavares; Jorge C Escalante-Semerena
Journal: Mol Microbiol Date: 2008-09-18 Impact factor: 3.501

Review 5. The kidney in leptospirosis.

Authors: Regina C R M Abdulkader; Marcos Vinicius Silva
Journal: Pediatr Nephrol Date: 2008-04-30 Impact factor: 3.714

6. Screening of a Leptospira biflexa mutant library to identify genes involved in ethidium bromide tolerance.

Authors: Helena Pětrošová; Mathieu Picardeau
Journal: Appl Environ Microbiol Date: 2014-07-25 Impact factor: 4.792

7. Comparative proteogenomic analysis of the Leptospira interrogans virulence-attenuated strain IPAV against the pathogenic strain 56601.

Authors: Yi Zhong; Xiao Chang; Xing-Jun Cao; Yan Zhang; Huajun Zheng; Yongzhang Zhu; Chengsong Cai; Zelin Cui; Yunyi Zhang; Yuan-Yuan Li; Xiu-Gao Jiang; Guo-Ping Zhao; Shengyue Wang; Yixue Li; Rong Zeng; Xuan Li; Xiao-Kui Guo
Journal: Cell Res Date: 2011-03-22 Impact factor: 25.617