| Literature DB >> 15064709 |
Bénédicte Delaval1, Alexia Ferrand, Nathalie Conte, Christian Larroque, Danièle Hernandez-Verdun, Claude Prigent, Daniel Birnbaum.
Abstract
Taxins are a family of centrosomal proteins important for the regulation of mitosis and microtubule dynamics. Cytokinesis, the last step of M phase, is essential for chromosomal integrity and cell division. It is highly regulated and involves a reorganization of microtubules and actin filaments. We show here that TACC1 localizes diffusely to the midzone spindle in anaphase and strongly to the midbody during cytokinesis, indicating a possible involvement of this protein in the exit of M phase. TACC1 also relocalizes to the nucleolus in interphase. We demonstrate that TACC1 and the mitotic kinase Aurora B belong to the same complex during cytokinesis. We further show that Aurora B knocked down by RNA-mediated interference prevents the formation of the midbody - and consequently affects TACC1 localization at this site - and leads to abnormal cell division and multinucleated cells.Entities:
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Year: 2004 PMID： 15064709 DOI： 10.1038/sj.onc.1207593
Source DB: PubMed Journal: Oncogene ISSN： 0950-9232 Impact factor: 9.867