Literature DB >> 15063470

Improvement in solubility and dissolution rate of flavonoids by complexation with beta-cyclodextrin.

Silvana Tommasini1, Daniela Raneri, Rita Ficarra, Maria Luisa Calabrò, Rosanna Stancanelli, Paola Ficarra.   

Abstract

The inclusion into the beta-cyclodextrin is used to improve pharmacokinetic characteristics of hesperetin and naringenin. Solubility of hesperetin and naringenin with increasing concentrations of beta-cyclodextrin grows as long as the temperature increased. Stability constants were determined by the solubility method by Higuchi and Connors at different temperatures, and the thermodynamic parameters were calculated for inclusion complex formation in aqueous solution. The solid complexes were obtained in a molar ratio of 1:1 and their dissolution behavior at different pH was examined.

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Year:  2004        PMID： 15063470     DOI： 10.1016/S0731-7085(03)00647-2

Source DB:  PubMed          Journal:  J Pharm Biomed Anal        ISSN： 0731-7085            Impact factor:   3.935


  25 in total

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Journal:  ACS Med Chem Lett       Date:  2019-01-29       Impact factor: 4.345

4.  The influence of cosolvent on the complexation of HP-beta-cyclodextrins with oleanolic acid and ursolic acid.

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5.  Enhancement of naringenin bioavailability by complexation with hydroxypropyl-β-cyclodextrin. [corrected].

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Journal:  PLoS One       Date:  2015-06-22       Impact factor: 3.240

7.  Physical properties and biological activities of hesperetin and naringenin in complex with methylated β-cyclodextrin.

Authors:  Waratchada Sangpheak; Jintawee Kicuntod; Roswitha Schuster; Thanyada Rungrotmongkol; Peter Wolschann; Nawee Kungwan; Helmut Viernstein; Monika Mueller; Piamsook Pongsawasdi
Journal:  Beilstein J Org Chem       Date:  2015-12-29       Impact factor: 2.883

8.  Spray Drying of Rhodomyrtus tomentosa (Ait.) Hassk. Flavonoids Extract: Optimization and Physicochemical, Morphological, and Antioxidant Properties.

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Journal:  Int J Food Sci       Date:  2014-12-04

9.  Colorimetric Detection of Some Highly Hydrophobic Flavonoids Using Polydiacetylene Liposomes Containing Pentacosa-10,12-diynoyl Succinoglycan Monomers.

Authors:  Deokgyu Yun; Daham Jeong; Eunae Cho; Seunho Jung
Journal:  PLoS One       Date:  2015-11-23       Impact factor: 3.240

10.  Host-Guest Inclusion Complexes between Amlodipine Enantiomers in the Biphasic Recognition Chiral Extraction System using Tartaric Acid and β-Cyclodextrin Derivatives as Positive Confirmation by using their Enantioselective Extraction.

Authors:  Khaldun M Al Azzam; Hassan H Abdallah; Hairul N Abdul Halim; Maizatul Akmam Ahmad; Hassan Shaibah
Journal:  Sci Pharm       Date:  2015-06-22
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