| Literature DB >> 15063011 |
Maki Matsubara1, Ichiro Sakata, Reiko Wada, Mami Yamazaki, Kinji Inoue, Takafumi Sakai.
Abstract
Ghrelin was recently identified as an endogenous ligand for GH secretagogue receptor. In this study, we investigated the effects of ovariectomy on the numbers of ghrelin-immunopositive and -expressing cells, ghrelin mRNA levels, and plasma ghrelin concentrations in 4- and 9-week-old female rats. Three days after ovariectomy, the number of ghrelin cells and plasma ghrelin level significantly increased in both 4- and 9-week-old rats and the ghrelin mRNA level also increased in 4-week-old rats. These responses were reversed by 17beta-estradiol replacement. We also found that ghrelin-immunopositive cells express estrogen receptor alpha. These results suggested that estrogen is involved in the regulation of ghrelin expression.Entities:
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Year: 2004 PMID： 15063011 DOI： 10.1016/j.peptides.2003.12.020
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750