Literature DB >> 1506273

Metabolism of tegafur in rat liver observed by in vivo 19F magnetic resonance spectroscopy and chromatography.

M Harada1, H Nishitani, K Koga, I Miura, Y Umeno.   

Abstract

Metabolism of tegafur in the rat liver was observed by in-vivo 19F magnetic resonance spectroscopy (MRS). After MRS observation, tegafur and q-fluorouracil (5-FU) in the liver were determined by a chromatographic method for comparison with the results of 19F-MRS. Rats were divided into 3 groups: 1) CCl4-induced liver injury group, 2) uracil combined group, 3) control group. Catabolism to fluoro-beta-alanine was suppressed in both the liver injury group and the uracil combined group. Low peaks of 5-FU and fluoronucleotides could be found only in the uracil combined group. The result of 19F MRS observation of each group was in agreement with the result of determination of tegafur and 5-FU by chromatography. This showed that substances which could be observed by 19F-MRS were in proportion to all intracellular fluoro-containing substances. 19F-MRS can provide direct information on the metabolism of fluoropyimidines non-invasively and it might be a useful aid in choosing suitable chemotherapy for patients.

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Year:  1992        PMID： 1506273      PMCID： PMC5918836          DOI： 10.1111/j.1349-7006.1992.tb00119.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  13 in total

1.  A new method for the evaluation of the liver injury by 19F MRS of 5-fluorouracil.

Authors:  M Harada; K Koga; I Miura; H Nishitani
Journal:  Magn Reson Med       Date:  1991-12       Impact factor: 4.668

2.  Experimental chemotherapy of carcinoma of the human stomach and colon serially transplanted in nude mice.

Authors:  T Kubota; Y Shimosato; K Nagai
Journal:  Gan       Date:  1978-06

3.  Biochemical basis for fluorouracil neurotoxicity. The role of Krebs cycle inhibition by fluoroacetate.

Authors:  H Koenig; A Patel
Journal:  Arch Neurol       Date:  1970-08

4.  Effect of uracil and its derivatives on antitumor activity of 5-fluorouracil and 1-(2-tetrahydrofuryl)-5-fluorouracil.

Authors:  S Fujii; K Ikenaka; M Fukushima; T Shirasaka
Journal:  Gan       Date:  1978-12

5.  The antitumor potency of oral tegafur against adenocarcinoma 755 in mice is markedly enhanced by oral (E)-5-(2-bromovinyl)-2'-deoxyuridine.

Authors:  M Iigo; Z Yamaizumi; S Nishimura; A Hoshi; E De Clercq
Journal:  Jpn J Cancer Res       Date:  1987-04

6.  Effect of coadministration of uracil or cytosine on the anti-tumor activity of clinical doses of 1-(2-tetrahydrofuryl)-5-fluorouracil and level of 5-fluorouracil in rodents.

Authors:  S Fujii; S Kitano; K Ikenaka; T Shirasaka
Journal:  Gan       Date:  1979-04

7.  The therapeutic effects of orally administered 5'-deoxy-5-fluorouridine, 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil on experimental murine tumors.

Authors:  N Uehara; H Baba; K Nitta; T Kunimoto; M Takeuchi; T Sasaki; T Tanaka
Journal:  Jpn J Cancer Res       Date:  1985-10

8.  Direct 19F NMR spectroscopic observation of 5-fluorouracil metabolism in the isolated perfused mouse liver model.

Authors:  S Cabanac; M C Malet-Martino; M Bon; R Martino; J F Nedelec; J L Dimicoli
Journal:  NMR Biomed       Date:  1988-06       Impact factor: 4.044

9.  High-pressure liquid chromatographic determination of ftorafur [1-(tetrahydro-2-furanyl)-5-fluorouracil] and GLC-mass spectrometric determination of 5-fluorouracil and uracil in biological materials after oral administration of uracil plus ftorafur.

Authors:  T Marunaka; Y Umeno; K Yoshida; M Nagamachi; Y Minami; S Fujii
Journal:  J Pharm Sci       Date:  1980-11       Impact factor: 3.534

10.  5-fluorouracil metabolism monitored in vivo by 19F NMR.

Authors:  A N Stevens; P G Morris; R A Iles; P W Sheldon; J R Griffiths
Journal:  Br J Cancer       Date:  1984-07       Impact factor: 7.640
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  1 in total

1.  Comparative studies on the metabolism of new fluorinated pyrimidine drugs in the liver by in vivo 19F magnetic resonance spectroscopic observation.

Authors:  M Harada; H Nishitani; K Koga; I Miura; A Kimura
Journal:  Jpn J Cancer Res       Date:  1993-02
  1 in total

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