| Literature DB >> 15062641 |
Sumathi Subramaniam1, Christine Stansberg, Charles Cunningham.
Abstract
Interleukin-1 is a key inflammatory cytokine that mediates its effects through a type I receptor and a receptor accessory protein. These two molecules are members of a wider family of proteins that have in common the presence of immunoglobulin domains in the extracellular region of the protein and a TIR domain in the cytoplasmic region. The nature of this family of proteins and their signal transduction pathway is discussed in this review.Mesh：
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Year: 2004 PMID： 15062641 DOI： 10.1016/j.dci.2003.09.016
Source DB: PubMed Journal: Dev Comp Immunol ISSN： 0145-305X Impact factor: 3.636