Major salivary gland cancer.

Major salivary gland cancers are rare, with many histologic types and subtypes. The tumor stage at presentation will dictate the need for imaging,FNA, and facial nerve monitoring. Immunohistochemistry has enhanced diagnosis. In addition, precise attention to surgical landmarks and technique will reduce complications. Tumor stage, histologic type, tumor grade,surgical margin, facial nerve dysfunction, perineural involvement, extra-parenchymal spread, and nodal metastasis are factors influencing the indication for neck dissection, postoperative radiation therapy, and survival rate.